Category Archives: Data Mining
IIIT-HYDERABAD HOSTS 27TH INTERNATIONAL CONFERENCE ON DATABASE SYSTEMS FOR ADVANCED APPLICATIONS (DASFAA 22) – Devdiscourse
Conference includes talks, research papers, tutorials, demos, industry presentations, panel discussions and workshops on database systems HYDERABAD, India, April 11, 2022 /PRNewswire/ -- IIIT Hyderabad is hosting the 27th International Conference on Database Systems for Advanced Applications (DASFAA 22) online from 11-14 April.
The Conference provides a leading international forum for discussing the latest research on database systems and advanced applications. DASFAA is a well-established international conference series that provides a forum for technical presentations and discussions among database researchers, developers, and users from academia, business, and industry, which showcases state-of-the-art R&D activities in the general areas of database systems, Web information systems, and their applications. The conference's long history has established the event as the premier research conference in the database area.
It includes 5 keynote talks, 143 research papers, 5 tutorials, 11 demos, 12 industry presentations, 6 workshops and 2 panel discussions.
The dominant topics include big data management, machine learning for database, graph data management, graph and social network analysis followed by text and data mining, data management in social networks, recommendation systems, search and recommendation technology, data semantics and data integration, crowdsourcing, spatial data management, network embedding, sequence and temporal data processing, temporal and spatial databases, large-scale knowledge management, RDF and knowledge graphs, social network and security, security, privacy and trust, medical data mining, bio and health informatics, query processing and optimization, text databases, search and information retrieval, information integration, information recommendation, multimedia databases, multimedia data processing, distributed computing, cloud data management, data archive and digital library, data mining and knowledge discovery, data semantics and integrity constraints, data model and query language, data quality and credibility, data streams and time-series data, data warehouse and OLAP, embedded and mobile databases, databases for emerging hardware, database usability and HCI, HCI for modern information systems, index and storage systems, information extraction and summarization, blockchain, parallel & distributed systems, parallel, distributed & P2P systems, parallel and distributed databases, probabilistic and uncertain data, real-time data management, Semantic Web and triple data management, Semantic Web and knowledge management, sensor data management, statistical and scientific databases, transaction management, Deep Web, Web data management, Web information systems, advanced database and Web applications, and XML, RDF and semi-structured data.
More details at https://www.dasfaa2022.org/ About IIIT-Hyderabad The International Institute of Information Technology, Hyderabad (IIIT-H) is an autonomous research university founded in 1998 that focuses on the core areas of Information Technology, such as Computer Science, Electronics and Communications, and their applications in other domains through inter-disciplinary research that has a greater social impact. Some of its research domains include Visual Information Technologies, Human Language Technologies, Data Engineering, VLSI and Embedded Systems, Computer Architecture, Wireless Communications, Algorithms and Information Security, Robotics, Building Science, Earthquake Engineering, Computational Natural Sciences and Bioinformatics, Education Technologies, Power Systems, IT in Agriculture and e-Governance.
Website: http://www.iiit.ac.in For further information, please contact: Sunory Dutt, Head of Communications, IIIT-Hyderabad E-mail: sunory.dutt@iiit.ac.in Logo: https://mma.prnewswire.com/media/600789/IIIT_Hyderabad_Logo.jpg PWR PWR
(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)
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Global Coated Recycled Paperboard Markets, 2022-2027 – Rise in Awareness of Eco-Friendly Packaging – ResearchAndMarkets.com – Business Wire
DUBLIN--(BUSINESS WIRE)--The "Global Coated Recycled Paperboard Market to 2027" report has been added to ResearchAndMarkets.com's offering.
Rise in awareness of eco-friendly packaging is the key driving factor which is expected to boost the global coated recycled paperboard market growth. Furthermore, increase in technological developments and innovations are expected to propel the global coated recycled paperboard market growth.
Also, increase in demand for coated recycled paperboard in printing and packaging sector is expected to fuel the growth of global coated recycled paperboard market.
However, stringent government rules and regulations and inability of the products to handle mechanical stress of heavy materials are the challenging factors which are expected to hamper the global coated recycled paperboard market growth.
Market Key Players
Key Topics Covered:
1 Introduction
1.1 Objective of the Study
1.2 Market definition
1.3 Market Scope
2 Research Methodology
2.1 Data Mining
2.2 Validation
2.3 Primary Interviews
2.4 List of Data Sources
3 Executive Summary
4 Global Coated Recycled Paperboard Market Outlook
4.1 Overview
4.2 Market Dynamics
4.2.1 Drivers
4.2.2 Restraints
4.2.3 Opportunities
4.3 Porters Five Force Model
4.4 Value Chain Analysis
5 Global Coated Recycled Paperboard Market, By Type
5.1 Y-o-Y Growth Comparison, By Type
5.2 Global Coated Recycled Paperboard Market Share Analysis, By Type
5.3 Global Coated Recycled Paperboard Market Size and Forecast, By Type
5.3.1 Calcium Carbonate
5.3.2 Kaolin Clay or China Clay
5.3.3 Titanium Dioxide
6 Global Coated Recycled Paperboard Market, By Application
6.1 Y-o-Y Growth Comparison, By Application
6.2 Global Coated Recycled Paperboard Market Share Analysis, By Application
6.3 Global Coated Recycled Paperboard Market Size and Forecast, By Application
6.3.1 Bakery Products
6.3.2 Home & Garden
6.3.3 Pet Food
6.3.4 Dry Foodstuffs
6.3.5 Cereal Cartons
6.3.6 Personal Care
6.3.7 Others
7 Global Coated Recycled Paperboard Market, By Region
7.1 Global Coated Recycled Paperboard Market Share Analysis, By Region
7.2 Global Coated Recycled Paperboard Market Share Analysis, By Region
7.3 Global Coated Recycled Paperboard Market Size and Forecast, By Region
For more information about this report visit https://www.researchandmarkets.com/r/ry06lm
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Global MABS Resin Markets, 2022-2027 – Focus on Medical Devices, Reusable Drinkware, Industrial Housing & Covers, Office Accessories and Toys -…
DUBLIN, April 11, 2022--(BUSINESS WIRE)--The "Global MABS Resin Market to 2027" report has been added to ResearchAndMarkets.com's offering.
MABS is referred as Methyl methacrylate-acrylonitrile-butadiene-styrene, which is an unmistakable design and item thermoplastic with phenomenal straightforwardness, great firmness, great protection and high quality. MABS is classified into various types such as High Impact Grade, High Rigidity Grade, General Purpose Grade, and Others.
Market Drivers
MABS is commonly called as undefined thermoplastic. It is copolymer of styrene, butadiene, acrylonitrile, methyl methacrylate and it has various mechanical properties like higher effect strength and straightforwardness.
Increase in demand for MABS resin due to its properties like high effect quality, great compound obstruction, and phenomenal straightforwardness which is expected to boost the global MABS resin market growth.
Market Restraint
However, availability of substitute is the major challenging factor which is expected to hamper the global MABS resin market growth.
Market Key Players
Key Topics Covered:
1 Introduction
1.1 Objective of the Study
1.2 Market definition
1.3 Market Scope
2 Research Methodology
2.1 Data Mining
2.2 Validation
2.3 Primary Interviews
2.4 List of Data Sources
3 Executive Summary
4 Global MABS Resin Market Outlook
4.1 Overview
4.2 Market Dynamics
4.2.1 Drivers
4.2.2 Restraints
4.2.3 Opportunities
4.3 Porters Five Force Model
4.4 Value Chain Analysis
5 Global MABS Resin Market, By Type
5.1 Y-o-Y Growth Comparison, By Type
5.2 Global MABS Resin Market Share Analysis, By Type
5.3 Global MABS Resin Market Size and Forecast, By Type
5.3.1 High Rigidity Grade
5.3.2 High Impact Grade
5.3.3 General Purpose Grade
5.3.4 Others
6 Global MABS Resin Market, By Application
6.1 Y-o-Y Growth Comparison, By Application
Story continues
6.2 Global MABS Resin Market Share Analysis, By Application
6.3 Global MABS Resin Market Size and Forecast, By Application
6.3.1 Medical devices
6.3.2 Reusable Drinkware
6.3.3 Industrial Housing & Covers
6.3.4 Office accessories
6.3.5 Toys
7 Global MABS Resin Market, By Region
7.1 Global MABS Resin Market Share Analysis, By Region
7.2 Global MABS Resin Market Share Analysis, By Region
7.3 Global MABS Resin Market Size and Forecast, By Region
For more information about this report visit https://www.researchandmarkets.com/r/3kuuvg
View source version on businesswire.com: https://www.businesswire.com/news/home/20220411005763/en/
Contacts
ResearchAndMarkets.comLaura Wood, Senior Press Managerpress@researchandmarkets.com
For E.S.T Office Hours Call 1-917-300-0470For U.S./CAN Toll Free Call 1-800-526-8630For GMT Office Hours Call +353-1-416-8900
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Evaluation of the Padua Prediction Score ability to predict venous thromboembolism in Israeli non-surgical hospitalized patients using electronic…
We evaluated the ability of the PPS to predict VTE in non-surgical hospitalized patients. The results did not demonstrate significant benefit of the PPS or the prophylactic anticoagulation based on it. The occurrence of recorded clinically significant VTE events in non-surgical patients during hospitalization and up to 90days thereafter was relatively low, about 1 event in 400 admissions, compared to previously reported estimations5,11.
The study results demonstrated a difference of 0.01% between the risk groups (0.27% vs. 0.28%) and the statistical analysis indicated that this difference in the studied sample size of about 15,000 patients is not statistically significant. The calculated sample size to show statistical significance of a difference of 0.1% (tenfold higher than the observed difference) is about 80,000 patients and for a difference of 0.01% (as was observed in the study) it is over 8 million patients. This means that a profoundly high number of patients would have to be treated to prevent a single VTE case, which exclude any clinical significance. The potential harm and high cost dramatically outweigh any benefit in this case.
The use of PPS was also not related to improved or worsen safety regarding bleeding events. The routine performance of PPS and the implementation of pharmacologic prophylaxis following PPS estimations involve substantial resources (medical personnel time, medication cost) and may distract physicians. Lack of beneficial effects calls to consider discontinuation of this practice to save resources.
While the presented study followed the Padua study outline, there is a marked difference between the VTE incidences observed in the studies, over tenfold. The diagnosis of VTE events in the Padua study was mainly based on positive imaging and laboratory (d-dimer) results and not on clinical symptoms5. A high percentage of the Padua study participants was referred to testing. Data regarding the clinical significance of the VTE diagnosis in the Padua study are limited. Contrary, the presented study identified recorded symptomatic clinically meaningful VTE events that demanded intervention or readmission. The different methods may have led to the different outcome rates. In addition, the duration of hospitalization was relatively longer in the Padua study, which may have contributed to the elevated VTE prevalence.
Others also found low efficiency of the PPS. Saliba et al. measured single thrombin generation in acutely hospitalized patients and found no correlation with the PPS12. Vardi et al. showed that PPS estimation lacks granularity in detecting non-surgical septic patients at risk of acquiring VTE13. Depietri et al. assessed the application of risk assessment models, including the PPS, on VTE and major hemorrhage on internal medicine hospitalized patients and found it statistically ineffective14.
The PPS was compared to other risk assessment tools. The Caprini risk assessment model (RAM) performed better than the PPS in 2 studies. Zhou et al. assessed the validity of the Caprini RAM in Chinese hospitalized patients with VTE and compared it to the Kucher tool and the PPS15. Caprini model was found to classify much more VTE patients into high or highest risk level than the other models with statistically significant differences (Caprini model vs Kucher model, p<0.0001; Caprini model vs the PPS, p<0.0001). In another study by Zhou et al. the Caprini RAM was compared again to thePPS16. The Cparini RAM defined 82.3% of VTE cases as high risk, while the PPS has defined only 30.1% of these same cases. Nendaz et al. investigated the Geneva risk score among Swiss hospitalized medical patients17. They found that for VTE prediction, the Geneva Risk Score compared favourably with the PPS, particularly for its accuracy to identify low-risk patients who do not require thromboprophylaxis. The main practical limitation of the Caprini and Geneva models is their relative complexity, as they include 39 and 19 criteria, respectively, compared to the 11 criteria of PPS.
PPS is a mathematical scoring method based on the models of Kucher et al. and Lecumberri et al. that uses some of the criteria in the original models18,19. Its ability to capture the full clinical complexity of different patients and become a globally generalized valid assessment tool is limited. Risk assessment should be comprehensive and appropriately tailored to the patients and the relevant population. In addition, risk should be continuously evaluated and not assessed only at a single time point, such as admission.
The issue of any VTE diagnosis vs. symptomatic VTE is paramount. The practical contribution of asymptomatic VTE diagnosis to patients health and prognosis can be debated. Hospital related VTE was considered a safety concern following 2 studies published in the late 1980s20,21. Both were based on autopsies of patients that died during hospitalization or shortly after. These studies only demonstrated the presence of VTE in the body; there was no proof of causality or any linkage between VTE post-mortem presence and either morbidity or mortality. The Worchester study from 1991 showed higher VTE rates in hospitalized patients compared to community; this study also reported mainly asymptomatic cases22. About 10years later (20022003), 3 large-scale clinical trials sponsored by pharmaceutical companies were published almost simultanesly23,24,25. They all demonstrated significant improvement in VTE incidence following prophylactic anticoagulants. A critical review of the studies by Vardi and Haran emphasized that most of the VTE cases in the clinical trials were asymptomatic26. Symptomatic VTE rates were low and there was no benefit for the prophylaxis when observing only symptomatic cases.
During the years, there were several other publications that supported the importance of VTE risk during hospitalization and immediately after but based their conclusion on previous papers that mainly cited the old autopsy studies. Pradonicoauthor of the Padua studycited Leizorovicz and Mismetti to support in his paper the claim regarding VTE elevated risk in non-surgical hospitalized patients27,28. Leizorovicz and Mismetti themselves have based this claim on the THRIFT study paper29, which provides as references the 1980s autopsy studies, again20,21. The claim that the risk for clinically meaningful VTE in non-surgical hospitalized patients is significantly elevated, is poorly substantiated on clear clinical data.
Diagnosis of asymptomatic VTE is increasing with the advances in diagnostic technologies. Computed tomography pulmonary angiography is able to pick up pulmonary emboli as small as 23mm in diameter, but their clinical relevance is questioned30,31. Unnecessary anticoagulation increases the risk for major bleedings32.
The pathophysiology of VTE is related to an imbalance of 3 components of the Virchovs triangle: hypercoagulability, stasis, and endothelial impairment33. This imbalance does not necessarily worsen upon admission to hospitalization for most non-surgical patients; it can even improve. The risk for VTE is inherent and relatively fixed due to the patients prolonged personal medical and functional status before admission. Many of these patients are functionally impaired and immobile long before their hospitalization, while immobility of hospitalized patients is usually properly addressed by repeated position changes and other means and procedures, as instructed by current guidelines and hospital accreditation standards34. Blood viscosity is improved upon admission of deteriorated or dehydrated patients using fluid therapy. Infection and inflammation are appropriately and rapidly managed in most admitted patients. These interventions during hospitalization, which are nowadays a common practice, reduce the risk for VTE and the need for pharmacological prophylaxis. Shortening of the hospitalization is another key element of mitigating the risk.
Recent studies have indicated a low incidence of symptomatic VTE in hospitalized non-surgical patients. Fritz et al. found that only 0.3% of general medicine hospitalized patients developed VTE35. Koren et al. evaluated over 500 Israeli medical hospitalized patients and did not find any hospital acquired symptomatic VTE36. Vardi et al. studied septic patients in Israeli internal medicine departments and found a low rate of symptomatic VTE13. Kolomansky et al. evaluated prospectively the occurrence of VTE in Israeli hospitalized patients. Overall, VTE was diagnosed in 0.25% of these patients37. These reports support the presented study results.
Another support to the low incidence of clinically significant VTE in hospitalized patients comes from a recently published OECD report on VTE rates38. The recorded multinational multicenter VTE hospital-related diagnosis is 0.3% (189.3 DVT cases and 175.3 PE cases of 100,000 discharges), similar to the present study results. It represents the true extent of the clinically meaningful VTE cases.
The study has limitations. It is retrospective and based of computerized retrieval of digital data. It is depended on the heterogenic quality of medical information recorded by numerous staff members. It is a single center study and the generalization of its conclusion should be done carefully.
Nevertheless, the study holds several strengths. It has a large patients sample, over 5,000. More than twice the sample of the Padua study, which was also a single center study. This study outline replicated the Padua study group design and patient selection to enable a fair chance for comparison. The study period is relatively long, over 2years, and the outcomes were measured up to 90days after discharge. The data were pooled from 2 medical databases providing comprehensive information from the hospital and community clinics; this gives high credence to the results. An independent focused validation was performed to ensure the appropriateness of the VTE diagnosis.
In conclusion, PPS was not found to be an efficient tool for identification of non-surgical hospitalized patients with high risk for clinically significant VTE events. Prophylactic anticoagulation based on PPS did not provide significant clinical benefit. The study results indicate the need to consider stopping the use of PPS as a mandatory or preferred assessment tool for VTE in Israeli non-surgical hospitalized patients. Until confirmed, better and efficient assessment tools can be implemented, it is recommended to clinically assess VTE risk and the need for prophylaxis in hospitalized non-surgical patients on a case by case basis.
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Is The Legal Function Fiddling While The Rule Of Law Is Burning? The Case For An Integrated Response – Forbes
CHARLOTTE, NC - SEPTEMBER 21: A police officer attempts to extinguish a fire on the I-85 (Interstate ... [+] 85) during protests in the early hours of September 21, 2016 in Charlotte, North Carolina. The protests began last night, following the fatal shooting of 43-year-old Keith Lamont Scott by a police officer at an apartment complex near UNC Charlotte. (Photo by Sean Rayford/Getty Images)
A categorical imperative would be one which represented an action as objectively necessary in itself, without reference to any other purpose. Immanuel Kant
At a time of profound change, upheaval, and uncertainty, individuals and society seek stability, accessibility, and wisdom from their institutions. How is the legal industry responding? Spoiler alert: neither adequately nor holistically.
The legal industry has not coalesced to address the erosion of public trust in lawyers and legal institutions, lack of access to legal services for most individuals and small/mid-sized businesses, and other systemic deficiencies. That undermines laws efficacy and erodes its societal impact at a time when both are badly needed.
Nor has the industry collectively explored why its demographic makeup, socio-economic homogeneityeven its vocabulary bear little resemblance to society-at-large. Examining why law has become so detached from the public is the first step towards rectification. The short answer to the why question is culture; the industry has failed to adapt to the ever-widening scope and accelerating pace of individual, business, and social change. It has largely ignored its role to protect and advance the rule of law and common good. Instead, most in the legal industry are focused on preserving the internal status quo
The legal establishment has also sidestepped other internal challengesits law schools antiquated, doctrinally-steeped pedagogy and one-size-fits-all approach; failure to recruit a diverse cohort with a learning-for-life mindset and invest in their upskilling that includes affordable self-help tools and experiential learning opportunities; lack of diversity, inequality, gender pay gap, usual suspect talent pool and emphasis on pedigree; and lack of collaboration/ team building. The legal industry devalues soft skillsempathy, resilience, inquisitiveness, and passion, among others. These are core attributes that not only contribute to professional success but also to human fulfillment.
An Industry That Has Lost Its Purpose
The legal industry lacks a central purpose. It is a fragmented, insular industry in search of meaning. Laws key internal stakeholders education, service providers, regulators, and the judiciary operate as guilds. Each has its own norms, pace, metrics, and structures. There is little collaboration, cohesion, or urgency among them to synchronize and advance collective objectives. Law has become a rudderless ship.
An asynchronous insular, siloed, precedent-bound, risk-averse, self-regulated, homogeneous, data-deficient industry lacking a reason for being cannot produce the bold, outcome-oriented, purpose-driven approach required to solve wicked problems. A full-throated, all-hands-on-deck defense of the rule of law is tops among them.
What is the purpose of the legal system and what role should each of its component parts play to achieve it? These are existential questions the legal industry must address, coalesce behind, and act upon.
A good place to start is the preamble of the American Bar Association Model Rules of Legal Ethics. It provides: [1] A lawyer, as a member of the legal profession, is a representative of clients, an officer of the legal system and a public citizen having special responsibility for the quality of justice. The legal profession has a special relationship with its customers (clients) as well as a strong social compact to set a high moral standard for the rest of society. If the legal profession serves only a small segment of those in need of its services, how can it act as steward of the quality of justice?
Ralph S. Tyler Jr., a Harvard constitutional law professor, considered the state of the legal profession in a recent New York Times Op Ed. His assessment is stark and unsettling: Something has gone badly wrong: It is unclear, in America in 2022, what the point of law is, what higher ends it should strive to attain. We have forgotten what law is for.
Tyler contends laws lack of purpose and pursuit of the common good pervades the profession/industry and imperils the rule of law. In his view, laws lost purpose extends all the way to the Supreme Court. He concludes that, The great promise of our legal systemthat law can create a framework to reconcile plural interests in a diverse society has manifestly failed. In his view laws abdication of the collective good and breach of its social compact indicate it has been infected by the same cancer that has metastasized in the body politic.
The witching hour for the legal industry to take concerted, meaningful action is fast approaching.
For Law, Its The Same Old Same Old
Key legal stakeholders continue to plod along, seemingly impervious to the convergent, convulsive changes transforming our lives, business, society, geopolitics, and environment. That t dilutes the legal functions societal impact, erodes public trust in the rule of law, and weakens an already flawed democracy. Worse still, there is no apparent urgency to take concerted action.
Students enroll in law schools, and 95% take out loans while the average grad is saddled with a $165,000 debt, not including interest. They lack practice-ready skills upon entry into the marketplace. Law schools continue to teach students how to think like a lawyer even as the legal role is being reconfigured not by lawyers but by business. Most full-time law school faculty have little or no practice or industry experience, understanding of the marketplace, or awareness of new career paths open to agile, inquisitive, team-oriented, and passionate grads.
Large corporate law firms continue to prosper even as their associate turnover rates and partner defections continue to rise. Meanwhile, their corporate (in-house) counterparts confront decreasing budgets, cost-takeout quotas, expanding portfolios, new risks, and an expectation that they not only defend the enterprise but also generate enterprise value and help enhance customer experience. Somethings got to give.
Courts are backlogged, opaque, and widely regarded as for the wealthy. Their laggard pace is out-of-synch with the speed of a digital world. The court of public opinion is increasingly challenging the hegemony of judicial resolution. Things do not have to be this way. As my good friend Richard Susskind has thoughtfully observed, courts can become a process, not a place. Whats lacking is the willingness of the judiciaryand the broader industryto challenge the status quo and to utilize available tools, resources, data, and new delivery models. These resourcesand a result-oriented approach to their utilizationwould improve access, efficiency, predictability, affordability, user-experience and scalability of dispute resolution, commercial transactions, regulatory compliance, and other functions.
Regulators routinely reject or nibble around the edges of legal modernization efforts. The remarkable rise of pro se litigants and default judgments in U.S. courts is the smoking gun in the case for re-regulation. Notwithstanding remarkable advances in technology, there is a dearth of self-help tools and affordable representation available to those that cannot afford a lawyer. As well, in many instances a licensed attorney is neither required nor the best equipped to respond to the challenge. Worse still, it is the legal profession that routinely opposes regulatory reform intended to better serve the public.
The legal profession is unhealthyliterally and figuratively. It suffers from high rates of suicide, chemical and alcohol dependency, divorce, and depression. A recent Atlantic article asserts that the legal profession has also become rife with partisanship, cancel culture, and ideological orthodoxy. The Constitution once united a diverse country under a banner of ideas. But partisanship has turned Americans against one anotherand against the principles enshrined in our founding document. Many lawyers have morphed from officers of the court to acolytes of orthodox ideologies.
The Takeover of Americas Legal System, another provocative indictment of the legal industry, contends law is infected by the same social forces that are fueling intolerance, doubt, and violence across society. The piece provides several examples of cancel culture and tribalism at U.S. law schools. It quotes a well-respected law professor who laments that: the imperatives of race, gender, and identity are more important to more and more students than due process, the presumption of innocence, and all the norms and values at the foundation of what we think of as the rule of law. Censorshipin the form of shutting down and/or ostracizing unpopular views or voiceshas become common at law schools and is increasingly evident at law firms and in the judiciary.
What To Do About It?
There are no quick or easy solutions to the aforementioned issues, but stasis is not a viable option. Here are some recommendations.
1. The legal industry, via leaders of its key stakeholder groups, must convene to establish its purpose.
2. Each stakeholder group plays a role in advancing the industry purpose. Collaboration, team-building, and integration between/among stakeholder groups is essential. It must become part of laws cultural fabric.
3. The legal industry must see itself as a function; it is part of a larger societal whole. Its purpose is not to serve lawyers but to serve justice and act as its steward.
4. The legal system should promote:
Humanity
Proactivity
Problem solving
Data mining, analytics, cross-functional sharing, and security
Data-backed recommendations
Transparency
Diversity
Multi-disciplinary collaboration
Industry benchmarks
Standardized terms
Self-help tools/solutions
Simple language
Business knowledge
Client-centricity (those that engage it and society-at-large)
Career-long learning centers
Up-skilling investment
Cultural awareness
Empathy
Speed
Accountability
Teamwork
Social responsibility
Diversity, equity, and inclusiveness
Synergy (internal and with other industries and society)
Agility
Accountability
Cost-effective solutions
Data-backed performance metrics available to the pubic
Competition (re-regulation)
Allied legal professionals (multidisciplinary workforce)
Diversified legal education programs tailored to different career paths
Impact on business and society
Global approach/collaboration to improve legal delivery
5. The legal industry should have fewer:
Unrepresented/under-represented individuals and businesses
Disputes that result in court proceedings
Lengthy contracts
Buzzwords and tech-hype
Innovation awards, self-proclaimed visionaries and disruptors, (and more thoughtful experimentation)
Law schools
Industry wide collaboration
Barriers to competition
Lawyers handling administrative matters and tasks that do not require legal licensure and/or can be done by machines
Examples of lawyers impeding commerce, not facilitating
Conclusion
The legal systems must serve the needs not only of clients that engage it but also society-at-large. Failure to do both is kryptonite to the rule of law and democracy. At a time when, for many, the rule of law is synonymous with political, ideological, and economic identification, the legal industry must adhere to a higher standard. It cannot look the other waymuch less participate in partisan conduct that violates its duty as an officer of the court and surrogate of the rule of law.
This is laws biggest case, and the stakes could not be higher.
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Complete Claim Investigations Faster with New Guidewire Marketplace App from Allied Universal Compliance and Investigations – Business Wire
SAN MATEO, Calif. & SANTA ANA, Calif.--(BUSINESS WIRE)--Guidewire (NYSE: GWRE) and Allied Universal Compliance and Investigations announced that Allied Universals new Ready for Guidewire add-on for Guidewire ClaimCenter is now available in the Guidewire Marketplace.
Insurance fraud results in monetary losses of billions of dollars every year, according to the Coalition Against Insurance Fraud. To combat insurance fraud, Allied Universal Compliance and Investigations partners with insurers and third-party administrators to shorten the cycle time for claim investigations, enabling them to better serve customers and more quickly bring claims to closure. Allied Universal Compliance and Investigations PartnerLink app for ClaimCenter streamlines the investigation process, allowing claim handlers to easily generate referrals and access information and files within ClaimCenter.
Allied Universal Compliance and Investigations customizes services to meet insurer needs across P&C, automobile, workers' compensation, and other coverage areas. The organizations approximately 10,000 professionals adhere to strict information management and operation security protocols, procedures, and compliance standards. PartnerLink integrates encrypted information within ClaimCenter, enabling adjusters to securely assemble, analyze and act on investigation data to build claim information, create real-time dashboards, and view business intelligence, optimizing efficiency and saving time.
With the Allied Universal Compliance and Investigations app for claim investigations, claim handlers can:
Our integration with Guidewire saves time and optimizes efficiency, said Michael J. Malone, president, Allied Universal Compliance and Investigations. In a secure environment, PartnerLink transforms investigations, providing access with a single click.
We congratulate Allied Universal Compliance and Investigations on the release of its PartnerLink app for investigative services for ClaimCenter, said Becky Mattick, vice president, Global Solution Alliances, Guidewire. Fraud continues to be prevalent, and this empowers insurers to quickly and effectively manage investigations and resolve claims.
About Allied Universal Compliance and Investigations
Allied Universal Compliance and Investigations is the global leader in insurance claims investigations. For 33 years, the Allied Universal name has been synonymous with the highest standards of integrity and service while offering fully integrated investigative solutions to the property and casualty markets. Allied Universal Compliance and Investigations provides unparalleled industry knowledge, superior data privacy, benchmarking, data mining and integrated technology backed by extensive global resources, expertise and proven return on investment. For more information, visit http://www.aus.com/cni.
About Allied Universal
Allied Universal, a leading security and facility services company, provides proactive security services and cutting-edge smart technology to deliver tailored, integrated security solutions that allow clients to focus on their core business. Through our vast global network of more than 800,000 employees, we leverage best practices in communities all over the world. With revenues of $20 billion, we are supported by efficient processes and systems that can only come with scale to help deliver our promise locally: keeping people safe so our communities can thrive. We believe there is no greater purpose than serving and safeguarding customers, communities, and people in todays world. Allied Universal is There for you. For more information, please visit http://www.aus.com.
About Guidewire PartnerConnect ecosystem and Ready for Guidewire
Guidewire PartnerConnect Solution partners provide software, technology, and data solutions as well as insurance support services. Our Solution partners help drive business value and innovation for insurers by developing and delivering integrations, extensions, apps, and other complementary solutions for Guidewire products. All of our Ready for Guidewire partner solutions are validated for security, quality, and compatibility with Guidewire, and can be found on the Guidewire Marketplace.
For more information about Guidewire PartnerConnect, please visit http://www.guidewire.com/partners.
About Guidewire Software
Guidewire is the platform P&C insurers trust to engage, innovate, and grow efficiently. We combine digital, core, analytics, and AI to deliver our platform as a cloud service. More than 450 insurers, from new ventures to the largest and most complex in the world, run on Guidewire.
As a partner to our customers, we continually evolve to enable their success. We are proud of our unparalleled implementation track record, with 1,000+ successful projects, supported by the largest R&D team and partner ecosystem in the industry. Our marketplace provides hundreds of applications that accelerate integration, localization, and innovation.
For more information, please visit http://www.guidewire.com and follow us on Twitter: @Guidewire_PandC.
NOTE: For information about Guidewires trademarks, visit https://www.guidewire.com/legal-notices.
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The Worldwide Connected Mining Industry is Expected to Reach $23.6 Billion by 2027 – PR Newswire
DUBLIN, April 4, 2022 /PRNewswire/ -- The "Connected Mining Market by Component (Solutions, Services), Solution (Asset Tracking and Optimization, Fleet Management), Service (Professional, Managed), Mining Type (Surface, Underground), Application, Deployment Mode & Region - Global Forecast to 2027" report has been added to ResearchAndMarkets.com's offering.
The publisher forecasts the Connected Mining Market size to grow from USD 12.7 billion in 2022 to USD 23.6 billion by 2027, at a Compound Annual Growth Rate (CAGR) of 13.3% during the forecast period.
The Solution segment to record the highest market share during the forecast period
In the Connected Mining Market by Component, solutions are expected to hold the largest market size. The connected solutions refer to the deployment of IoT solutions in the mining industry. These solutions are primarily aimed at achieving the convergence of machines and intelligent data to achieve the operational efficiency targets set by energy companies. connected solutions in mining sector also improvise analytics-based decision-making by diminishing the threats and vulnerabilities of the market using efficient tools and techniques. Moreover, connected mining solutions have enabled energy companies to control assets from anywhere to monitor their asset performance.
The Asset tracking and optimization segment to record the highest market share during the forecast period
In the Connected Mining Market by Solutions, the asset tracking and optimization segment is expected to record a larger market share during the forecast period. Asset tracking solutions do track mining assets, automating processes, and constantly monitoring the quality and safety of the mining environment. This helps ensure the mine and workers are efficient and productive. It involves tracking of mining vehicles in real-time, including GPS location, engine hours, mileage, geofences, and fuel consumption. To track underground mining assets while reducing costs, Real-Time Location Systems (RTLS), RFID tracking, Wi-Fi, sensors, mobile devices, software, and other technologies are used to gain full visibility of underground mining operations. The solution offers improved worker safety by tracking mine workers, monitoring entrances/exits and evacuation status, and receiving alerts.
The Professional Service segment to record the highest market share during the forecast period
In the Connected Mining Market by Service, Professional service segment is expected to hold a larger market share in 2027. Professional services consist of consulting services, system integration services, and support and maintenance. Consulting services primarily focus on managing the business operation revolution programs and the latest technology updates to help the client achieve strategic business goals through technical and business improvements. Integration is the process of connecting different subsystems or components into a single larger system, enabling it to work as a single IoT system. Integration and deployment services consolidate different technology products and applications, including legacy platforms, and can significantly reduce IT-related complexities and maximize the firm's RoI. Support and maintenance services category includes 24*7 customer support services, repair and exchange services, version maintenance, bug fixes, technical updates, license upgrades, proactive, and training services.
Cloud segment expected to have a higher growth rate during the forecast period
By Deployment mode, cloud segment is expected to lead the market during the forecast period. Cloud computing is one of the most effective technologies today, and it has impacted every line of business. In this deployment mode, connected mining solutions are delivered through the cloud. The advantages of deploying cloud-based mining solutions include scalability, speed, 24x7 service, enhanced IT security, affordability, operational efficiency, flexibility, and low costs. The overall adoption of cloud-based solutions is growing at a good pace, and the trend is expected to increase during the forecast period. Cloud platforms are new emerging development to track health of assets.
The Exploration segment to record the highest market share during the forecast period
By Application, exploration segment is expected to hold a larger market share during the forecast period. Exploration in the mining industry is a series of activities used to analyze or identify the availability of minerals and metals such as coal, ore, diamond, oil, and gas, under the ground. This process involves mapping, surveying the ground, testing water and soil quality, and drilling. Today, the exploration process in the mining industry is rapidly adopting technological, automotive, and digitalized solutions. Modern explorational techniques are greatly driven by technological solutions and various companies and government bodies are heavily investing in exploration technologies. Since 1950's to 1980's, exploration in mining has shown a rapid growth and remarkable success. The exploration industry observed few challenges in the last few years and their expenditure has also been increased due to some reasons such as new mines needed to locate at a high depth, minerals are available in location with large geoscience complexities, and others. With the increasing cost of exploration at high-risk organizations are becoming cautious and more dependent on geographic information. However, various technologies such as IoT, big data, and analytics, have adopted by miners to access reliable information of mine sites. Wipro helped Vedanta by providing real-time visibility in 890 production parameters and 708 quality parameters of its refinery unit.
Asia Pacific is expected to have a higher growth rate during the forecast period
Asia Pacific is expected to hold the largest market size in the global Connected Mining Market during the forecast period. In Asia Pacific, China, India, Indonesia, Papua New Guinea (PNG), and the Philippines are expected to drive the market with China as the most potential player in smart mining initiatives. India can be considered to be the next high potential preference for the major global connected mining market vendors as the country has increasing demand for minerals. New investments will drive the Indian market, following the country's ambitious target of adding USD 210 billion from the mining and mineral sectors to the country's GDP by 2050. The increase in production capacities in the region is driven by investment programs. This region is witnessing a high rate of adoption of technologies, such as operational analytics and data processing, remote monitoring, and mine safety systems.
Key Topics Covered:
1 Introduction
2 Research Methodology
3 Executive Summary
4 Premium Insights4.1 Brief Overview of the Market4.2 North America: Market, Top Three Solutions and by Mining Type4.3 Europe: Market, Top Three Solutions and by Mining Type4.4 Asia-Pacific: Market, Top Three Solutions and by Mining Type
5 Market Overview and Industry Trends5.1 Introduction5.2 Market Dynamics5.2.1 Drivers5.2.1.1 Mining 4.0 Initiatives in Industries, Paving the Way for Connecting Mining5.2.1.2 Need to Reduce Cost and Achieve Operational Efficiency to Boost the Adoption of Connected Mining Solutions5.2.1.3 Increasing Adoption of IoT to Accelerate the Use of Digital Solutions to Develop Connected Mines5.2.1.4 to Enhance the Safety and Security of Mine Workers5.2.2 Restraints5.2.2.1 Depletion of Natural Resources5.2.3 Opportunities5.2.3.1 Increasing Demand for Digitalization to Boost the Market5.2.3.2 Need of Metals and Minerals to Increase the Demand for Connected Mining Solutions5.2.3.3 Emerging 5G Technology to Help Connected Mining Adoption Globally5.2.4 Challenges5.2.4.1 Shortage of Skilled Labor5.2.4.2 Integrating Information Technology with Operational Technology5.3 COVID-19 Market Outlook for the Market5.4 Value Chain Analysis5.5 Ecosystem5.6 Porter's Five Forces Model5.7 Patent Analysis5.8 Pricing Analysis5.9 Technology Analysis5.10 Key Conferences and Events in 2022-20235.11 Regulations Landscape5.12 Case Study Analysis5.12.1 Case Study 1: Implementation of Accenture Life Safety Solution to Achieve Operational Efficiency5.12.2 Case Study 2: Shell and IBM Developed Oren to Support Digital Transformation for the Mining Industry5.12.3 Case Study 3: Significant Growth in the Production Capacity Has Been Observed with the Help of Hitachi Machinery5.12.4 Case Study 4: Deployment of Cisco's Connected Mining Solutions to Support Digital Transformation5.12.5 Case Study 5: Deployment of Velocity Ehs to Improve Safety Standards5.13 Key Stakeholders and Buying Criteria5.13.1 Key Stakeholders in Buying Process5.13.2 Buying Criteria
6 Connected Mining Market, by Component6.1 Introduction6.2 Solutions6.2.1 Solutions: Market Drivers6.2.2 Solutions: COVID-19 Impact6.3 Services6.3.1 Services: Market Drivers6.3.2 Services: COVID-19 Impact
7 Connected Mining Market, by Solution7.1 Introduction7.2 Asset Tracking and Optimization7.2.1 Asset Tracking and Optimization: Market Drivers7.2.2 Asset Tracking and Optimization: COVID-19 Impact7.3 Fleet Management7.3.1 Fleet Management: Connected Mining Market Drivers7.3.2 Fleet Management: COVID-19 Impact7.4 Industrial Safety and Security7.4.1 Industrial Safety and Security: Market Drivers7.4.2 Industrial Safety and Security: COVID-19 Impact7.5 Workforce Management7.5.1 Workforce Management: Market Drivers7.5.2 Workforce Management: COVID-19 Impact7.6 Analytics and Reporting7.6.1 Analytics and Reporting: Connected Mining Market Drivers7.6.2 Analytics and Reporting: COVID-19 Impact Drivers7.7 Process Control7.7.1 Process Control: Market Drivers7.7.2 Process Control: COVID-19 Impact7.8 Other Solutions7.8.1 Other Solutions: Market Drivers7.8.2 Other Solutions: COVID-19 Impact
8 Connected Mining Market, by Service8.1 Introduction8.2 Professional Services8.2.1 Professional Services: Market Drivers8.2.2 Professional Services: COVID-19 Impact8.2.3 Consulting8.2.4 Integration and Deployment8.2.5 Support and Maintenance8.3 Managed Services8.3.1 Managed Services: Market Drivers8.3.2 Managed Services: COVID-19 Impact
9 Connected Mining Market, by Application9.1 Introduction9.2 Exploration9.2.1 Exploration: Market Drivers9.2.2 Exploration: COVID-19 Impact9.3 Processing and Refining9.3.1 Processing and Refining: Market Drivers9.3.2 Processing and Refining: COVID-19 Impact9.4 Transportation9.4.1 Transportation: Market Drivers9.4.2 Transportation: COVID-19 Impact
10 Connected Mining Market, by Deployment Mode10.1 Introduction10.2 On-Premises10.2.1 On-Premises: Market Drivers10.2.2 On-Premises: COVID-19 Impact10.3 Cloud10.3.1 Cloud: Market Drivers10.3.2 Cloud: COVID-19 Impact
11 Connected Mining Market, by Mining Type11.1 Introduction11.2 Surface11.2.1 Surface: Market Drivers11.2.2 Surface: COVID-19 Impact11.3 Underground11.3.1 Underground: Market Drivers11.3.2 Underground: COVID-19 Impact
12 Connected Mining Market, by Region
13 Competitive Landscape13.1 Overview13.2 Market Evaluation Framework13.3 Key Player Strategies13.3.1 Product Launches13.3.2 Deals13.4 Market Share Analysis of Top Players13.5 Historical Revenue Analysis13.6 Company Evaluation Matrix Overview13.6.1 Company Evaluation Matrix Methodology and Definitions13.6.2 Star13.6.3 Emerging Leaders13.6.4 Pervasive13.6.5 Participants13.7 Company Product Footprint Analysis13.8 Company Market Ranking Analysis13.9 Startup/SME Evaluation Matrix Methodology and Definitions13.10 Competitive Benchmarking13.10.1 Progressive Companies13.10.2 Responsive Companies13.10.3 Dynamic Companies13.10.4 Starting Blocks
14 Company Profiles14.1 Major Companies14.1.1 Cisco14.1.2 IBM14.1.3 Accenture14.1.4 Caterpillar14.1.5 ABB14.1.6 Sap14.1.7 Schneider Electric14.1.8 Komatsu14.1.9 Hexagon14.1.10 Rockwell Automation14.1.11 Trimble14.1.12 Hitachi Construction Machinery14.1.13 Ptc14.1.14 Eurotech Communication14.1.15 Getac14.1.16 Siemens14.1.17 Howden14.1.18 Wipro14.1.19 Mst Global14.1.20 GE Digital14.2 Startup/SMEs Players14.2.1 Zyfra14.2.2 Axora14.2.3 Groundhog14.2.4 Smartmining14.2.5 Applied Vehicle Analysis14.2.6 Symboticware14.2.7 Intellisense.io
15 Adjacent Market
16 Appendix
For more information about this report visit https://www.researchandmarkets.com/r/kmgcyq
Media Contact:
Research and Markets Laura Wood, Senior Manager [emailprotected]
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The Worldwide Connected Mining Industry is Expected to Reach $23.6 Billion by 2027 - PR Newswire
Filings buzz in the mining industry: 13% decrease in digitalisation mentions in Q4 of 2021 – Mining Technology
Mentions of digitalisation within the filings of companies in the mining industry fell 13% between the third and fourth quarters of 2021.
In total, the frequency of sentences related to digitalisation during 2021 was 538% higher than in 2016 when GlobalData, from which our data for this article is taken, first began to track the key issues referred to in company filings.
When companies in the mining industry publish annual and quarterly reports, ESG reports, and other filings, GlobalData analyses the text and identifies individual sentences that relate to disruptive forces facing companies in the coming years. Digitalisation is one of these topics companies that excel and invest in these areas are thought to be better prepared for the future business landscape and better equipped to survive unforeseen challenges.
To assess whether digitalisation is featuring more in the summaries and strategies of companies in the mining industry, two measures were calculated. Firstly, we looked at the percentage of companies that have mentioned digitalisation at least once in filings during the past 12 months this was 61% compared to 29% in 2016. Secondly, we calculated the percentage of total analysed sentences that referred to digitalisation.
Of the 10 biggest employers in the mining industry, Sibanye-Stillwater was the company that referred to digitalisation the most during 2021. GlobalData identified 109 digitalisation-related sentences in the South Africa-based company's filings 0.6% of all sentences. Nippon Steel mentioned digitalisation the second most the issue was referred to in 0.5% of sentences in the company's filings. Other top employers with high digitalisation mentions included Honeywell, ThyssenKrupp, and Mitsubishi.
Across all companies in the mining industry, the filing published in the fourth quarter of 2021 that exhibited the greatest focus on digitalisation came from Orica. Of the document's 2,315 sentences, 20 (0.9%) referred to digitalisation.
This analysis provides an approximate indication of which companies are focusing on digitalisation and how important the issue is considered within the mining industry, but it also has limitations and should be interpreted carefully. For example, a company mentioning digitalisation more regularly is not necessarily proof that they are utilising new techniques or prioritising the issue, nor does it indicate whether the company's ventures into digitalisation have been successes or failures.
In the last quarter, companies in the mining industry based in Eastern Europe were most likely to mention digitalisation with 0.6% of sentences in company filings referring to the issue. In contrast, companies with their headquarters in the US mentioned digitalisation in just 0.09% of sentences.
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Sphere 3D Corp. and Gryphon Digital Mining, Inc. Move Forward After Mutual Agreement Not to Proceed With Merger – Business Wire
TORONTO, Ontario--(BUSINESS WIRE)--Sphere 3D Corp. (Nasdaq: ANY), (Sphere 3D) and Gryphon Digital Mining, Inc. (Gryphon), cryptocurrency mining companies dedicated to growing mining operations with a net carbon-neutral impact, have mutually agreed to terminate their merger agreement announced on June 3, 2021, and as amended on December 29, 2021.
After careful consideration by both management teams and their respective boards of directors, the parties amicably agreed to the termination due to changing market conditions, the passage of time, and the relative financial positions of the companies, among other factors. The companies will continue their relationship through the previously disclosed Master Services Agreement (MSA), enabling Sphere 3D to leverage Gryphons expertise in bitcoin mining and Gryphon to generate additional operating income through the management of Sphere 3Ds mining fleet. Both companies can now focus on their strategic opportunities to drive growth for their respective shareholders.
Sphere 3Ds net-carbon neutral bitcoin mining operation continues to grow with 1,000 miners currently operational and the anticipated delivery of 2,000 S19j Pro miners in May 2022 and an additional 2,000 S19j Pro miners in June 2022. Deliveries of the remaining 55,000 S19j Pro miners are expected to be received by year-end 2022. As previously announced, Sphere 3Ds mining fleet will remain managed by Gryphon and primarily collocated with Core Scientific.
Gryphon continues to roll out its net carbon-neutral bitcoin mining operation, with two-thirds of its 7,200 S19j Pro self-mining operation deployed as of March 31, 2022. The MSA enables Gryphon to earn additional hashrate exposure of 1.35 exahash through the management of Sphere 3Ds 6.0 exahash mining fleet, creating Gryphons expected effective unlevered total hashrate from self-mining and MSA operations of approximately 2.1 exahash of bitcoin mining power by year-end 2022.
Sphere 3D remains committed to building a premier industrial mining operation and already has 6.0 EH/s of capacity under contract for deliveries this year. We are well-positioned to execute on this vision, said Duncan McEwan, Chairman of Sphere 3D. The Board has worked closely with our management team, and after extensive discussions, it became clear that shareholders would realize greater value if the companies operated independently as opposed to a merged entity. We look forward to working closely with the Gryphon team to combine our expertise and realize the immense value of the bitcoin network for our shareholders.
Rob Chang, CEO at Gryphon Digital Mining added, As a pending shareholder and operating partner of Sphere 3D, we look forward to the mutual success of both companies. With a substantial unlevered total hashrate from our self-mining and MSA operations, Gryphon is well-positioned as it already ranks among the leading bitcoin miners in the world.
About Sphere 3D Corp
Sphere 3D Corp. (Nasdaq: ANY) is a net carbon-neutral cryptocurrency miner with decades of proven enterprise data-services expertise. The Company is rapidly growing its industrial-scale mining operation through the capital-efficient procurement of next-generation mining equipment and partnering with best-in-class data center operators. Sphere 3Ds mining operation currently has 1,000 S19j Pro miners operating, expects delivery of 4,000 more in the second quarter of 2022 and 55,000 additional S19j Pro miners by year-end 2022. Sphere 3D has approximately 6.0 EH/s of capacity under contract for deliveries this year. Sphere 3D is dedicated to growing shareholder value while honoring its commitment to strict environmental, social, and governance standards. For more information about the Company, please visit Sphere3D.com.
About Gryphon Digital Mining
Gryphon Digital Mining is an innovative venture in the cryptocurrency space dedicated to helping bring digital assets onto the clean energy grid. With a talented leadership team coming from globally recognized brands, Gryphon Digital is assembling thought leaders to improve digital asset network infrastructure. Its Bitcoin mining operation has a net carbon-negative footprint, and the companys long-term strategy is to be the first vertically integrated crypto miner with a wholly-owned, 100 percent renewable energy supply. More information is available on https://gryphondigitalmining.com/.
Forward-Looking Statements
This communication contains forward-looking statements within the meaning of Section 27A of the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements generally relate to future events, including the timing of the proposed transaction and other information related to the proposed transaction. In some cases, you can identify forward-looking statements because they contain words such as may, will, should, expects, plans, anticipates, could, intends, target, projects, contemplates, believes, estimates, predicts, potential or continue or the negative of these words or other similar terms or expressions. Expectations and beliefs regarding matters discussed herein may not materialize, and actual results in future periods are subject to risks and uncertainties that could cause actual results to differ materially from those projected. The forward-looking statements contained in this communication are also subject to other risks and uncertainties, including those more fully described in filings with the SEC, including Sphere 3Ds registration statement on Form F-4, reports filed on Form 20-F and Form 6-K and in other filings made by Sphere 3D with the SEC from time to time and available at http://www.sec.gov. These forward looking statements are based on current expectations, and with regard to the proposed transaction, are based on Sphere 3Ds and Gryphons current expectations, which are subject to change.
No Offer or Solicitation
This communication shall not constitute a solicitation of proxy, an offer to sell, the solicitation of an offer to sell or an offer to buy or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended.
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Creating databases to help cure diseases worldwide – University of Georgia
Jessica Kissinger never set out to make databases. From the time she was a little girl, she wanted to be a biologist.
Today, the University of Georgia professor not only studies deadly pathogens like malaria and Cryptosporidium (a waterborne parasite), but also is a driving force behind worldwide, groundbreaking collaborations on novel databases. During her time at UGA, she has received nearly $40 million in federal and private grants and contracts.
These databases can crunch vast amounts of biological information at warpspeed and reveal important patterns that pave the way for new approaches to scourges such as Leishmania (common in the tropics, subtropics, and southern Europe), toxoplasmosis (a systemic disease due to one of the worlds most common parasites), and Valley Fever (a fungus born on the wind that can cause lung and systemic infections). Novel drug and vaccine targets can be developed, as well as fresh insights on life-threatening pathogens.
Fighting infections and developing new drug and vaccine targets requires detailed knowledge of a pathogen and how it functions, explained Kissinger, a Distinguished Research Professor in UGAs Department of Genetics, Institute of Bioinformatics and Center for Tropical and Emerging Global Diseases.
And, like internet searches, the databases are all free. Kissinger said its likely that pharmaceutical companies are mining some of the information in their quest to discover new therapeutic targets.
They dont tell us what theyre working on, she said. A database itself doesnt produce a cure. A database can, however, remove most barriers to analysis of existing data.
It once took an entire decade to sequence a single genomeand the cost was many millions. Today, researchers can sequence a genome in a single afternoon for a few thousand dollars, transforming the field of genomics. Similar astounding advances have reshaped other omics specialties, such as proteomics (study of proteins), metabolomics (study of metabolism), transcriptomics (study of RNA), and epigenomics (the influence of the environment on gene function). These advances mark the Big Data era in biology.
The power that is unleashed by big data is phenomenal, said Kissinger, and its a very exciting time in history, with major funders and visionaries all across the world forming consortia to create a kind of ideal data universe. Like explorers trekking into a new world, they will make discoveries we might only imagine right now.
Kissingers innovations began over 23 years ago, while she was a postdoctoral researcher at the University of Pennsylvania studying a single-celled parasite called Toxoplasma gondii. The parasite shares some important features with the malaria pathogen, whose genome was in the process of being sequenced.
I rounded up genome data from all over the world on Plasmodium (the causative agent of malaria), and ran analyses and put it on a website, so I could study the genes it might share with Toxoplasma, she recalled. It turns out nobody had made the Plasmodium data available for searching before.
Soon she and her adviser, David Roos, had a million-dollar grant to formally establish a malaria database, PlasmoDB, and since its launch in 1999 it has grown to include additional pathogens and received continual funding from the NIH, the most recent for up to $38.4 million to maintain what has now become the Eukaryotic Pathogen, Vector and Host Informatics Resources knowledgebase (VEuPathDB), covering 14 different pathogens as well as host responses to infections. This comprehensive database is an integrated centralized resource for data mining on over 500 organisms.
The databases collectively contain over nine terabytes (9,000 gigabytes) of data, and have been compared to a Wikipedia for molecular parasitology by the British Society for Parasitology, which noted back in 2006: We dont know what we would do without it!
Each month, VEuPathDB receives over 11 million hits from an average of 36,000 unique visitors in more than 100 countries, including India, Brazil and Kenya. A related database on vectors of disease (such as ticks that carry Lyme disease) was recently merged into VEuPathDB. The merger expanded each resource and enables researchers to better explore data on vectors such as ticks and mosquitoes and the pathogens they transmit.
The databases are not just strings of numbers or words. They allow visualizations and graphic interfaces. Already, research is emerging that can help direct vaccine and drug development away from proteins that hosts and pathogens share, in order to protect the cell. Scientists using the databases have discovered proteins that reduce severe malaria and other proteins that protect malaria parasites from the human fever response. They have also found proteins that help Toxoplasma penetrate host cells.
In a single year an average of 200 publications a month cite VEuPathDB, and to date there have already been 24,000 citations total. Next up: cloud-ready applications and improved integration with yet other databases. These databases have become essential data mining and access platforms for fungal and parasite genomics research, said microbiologist and plant pathologist Jason Stajich of the University of California at Riverside.
Without powerful, user-friendly tools to analyze it, Big Data is more a curse than a blessing, explained John Boothroyd, an immunologist and microbiologist at Stanford University School of Medicine. VEuPathDB is just such a tool and we owe Jessica Kissinger and her colleagues an enormous thank you for their tireless and selfless efforts to first conceive and then continuously improve this absolutely essential resource.
Grants for related projects have come from a wide array of organizations, among them the Bill & Melinda Gates Foundation, the Sloan Foundation, and the World Health Organization. One of those projects, called ClinEpiDB, is home to a multicenter study that contains data from over 22,000 children from seven different sites in South Asia and Africa. This study is the largest ever to investigate the causes of diarrhea in children in lower- to middle-income countries. Other uses of ClinEpiDB include new data on hidden signs of malaria transmission in areas where incidence is declining, or how breastfeeding protects infants from common infections.
The VEuPathDB database would be enough to secure Kissingers reputation in the biological sciences, but she has not stopped there. At the University of Georgia, she was a founding member of the Institute of Bioinformatics, and served as its director from 2011 to 2109. The Institutes mission is to facilitate cutting-edge interdisciplinary research in computational biology, and the program offers both masters and doctorates. She is a key researcher helping to partner a national hub for infectious disease research by linking with Emory University in Atlanta. The two institutions have grants totaling over $45 million to work on everything from tuberculosis to HIV to malaria.
These databases are a success beyond my wildest dreams, said Kissinger. They are made by biologists for other biologists and address a real-life need.
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Creating databases to help cure diseases worldwide - University of Georgia