Category Archives: Engineering
Ginkgo Bioworks Strengthens End-to-End R&D Capabilities in Gene … – PR Newswire
Platform includes large library of existing capsids, which have been optimized for performance and targeting across a range of application areas through validation in large animal models
The addition of StrideBio's structure-guided AAV engineering capabilities combined with Ginkgo's already extensive assets make Ginkgo a unique one-stop shop capable of providing R&D services for gene therapy manufacturing across capsid, payload, and cell line optimization
As part of the transaction, Ginkgo also receives IP and data for StrideBio's lead preclinical asset for Arrhythmogenic Right Ventricular Cardiomyopathy, a rare genetic heart disease, which Ginkgo plans to sell or outlicense to a commercial partner
BOSTON, April 5, 2023 /PRNewswire/ --Ginkgo Bioworks (NYSE: DNA), which is building the leading platform for cell programming and biosecurity, today announced the acquisition of StrideBio's adeno-associated virus (AAV) capsid discovery and engineering platform assets with a secondary close scheduled upon the transfer of certain additional in-license agreements to Ginkgo. Ginkgo will incorporate these capabilities and IP into its end-to-end AAV gene therapy development platform, allowing Ginkgo's customers to leverage new tools to effectively target many different tissue types, and potentially to improve the safety profile of their future gene therapies. Ginkgo is also receiving StrideBio's existing library of capsids, which includes advanced candidates extensively tested in large animal models, and which are now available for licensing and broader partnership. Additionally, Ginkgo receives the IP and data for StrideBio's lead preclinical asset for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), a rare genetic heart disease, which Ginkgo plans to sell or outlicense to a commercial partner. The acquisition is focused on the enabling platform IP of StrideBio and does not include any real estate. One employee of StrideBio will transfer to Ginkgo as part of the transaction, joining Ginkgo's mammalian engineering team.
AAV remains the preferred viral vector for gene therapy, used in hundreds of active clinical trials. However, pharmaceutical developers focusing on AAV still face challenges pertaining to limitations in targeted biodistribution, pre-existing immunogenicity and manufacturability. StrideBio's STRIVE platform which uses a structural-engineering approach for generating novel AAV capsids to address these limitations has produced a library of candidates that includes mature assets with strong evidence demonstrated for both performance and targeting across multiple animal models.
StrideBio's platform generates capsids that are designed to overcome current limitations of first-generation gene therapies, including reduced seroprevalence, improved tropism for cell types beyond the liver such as those in the central nervous system and muscle tissue, and increased gene transfer efficiency, with the potential for improved safety and reduced doses in the clinic.
"The StrideBio team has built a deep pipeline of AAV capsids and libraries to address critical challenges facing clinical gene therapy with a focus on reducing vector dose and improving safety by limiting off-target biodistribution," said Aravind Asokan, Ph.D, who co-founded StrideBio with Pat Ritschel and the late Mavis Agbandje-McKenna. "With Ginkgo's expertise and scale, we hope to amplify this effort and deploy this platform to the gene therapy industry and ultimately, patients."
"Combining Ginkgo's engineering and discovery capabilities in enzymes, regulatory elements, and capsids enables a holistic approach to designing an AAV gene therapy, so that we can support our partners across the entire process of designing the viral vector," said Narendra Maheshri, Head of Mammalian Engineering at Ginkgo. "We are thrilled to integrate the STRIVE platform and know-how into our foundry to augment our capabilities in capsid engineering, and we look forward to continuing to expand our existing end-to-end capabilities in AAV discovery and manufacturing."
Ginkgo has significantly expanded its work and capabilities in gene therapy in recent years by acquiring Circularis' proprietary circular RNA and promoter screening platform, partnering with Biogen to improve AAV manufacturing, and partnering with Selecta Biosciences to develop AAV capsids with altered tropism and immunogenicity. Ginkgo has developed several capabilities which enhance its ability to leverage assets like those in this acquisition, including its ability to efficiently and quickly generate a massive set of candidates for testing, its scaled approach to protein engineering, and its ability to apply sequencing and computational pipelines to accelerate the analysis of capsid effectiveness in tissues of interest. To discuss how you can benefit from Ginkgo's biopharma and life science R&D capabilities, sign up for Ginkgo Office Hours to speak with our team today.
Foley Hoag LLP is providing legal counsel to Ginkgo, while Ropes & Gray LLP is serving as legal advisor to StrideBio.
About Ginkgo Bioworks
Ginkgo Bioworks is the leading horizontal platform for cell programming, providing flexible, end-to-end services that solve challenges for organizations across diverse markets, from food and agriculture to pharmaceuticals to industrial and specialty chemicals. Ginkgo's biosecurity and public health unit, Concentric by Ginkgo, is building global infrastructure for biosecurity to empower governments, communities, and public health leaders to prevent, detect and respond to a wide variety of biological threats. For more information, visit ginkgobioworks.com and concentricbyginkgo.com, read our blog, or follow us on social media channels such as Twitter (@Ginkgo and @ConcentricByGBW), Instagram (@GinkgoBioworks and @ConcentricByGinkgo), or LinkedIn.
Forward-Looking Statements of Ginkgo Bioworks
This press release contains certain forward-looking statements within the meaning of the federal securities laws, including statements regarding the capabilities and potential success of the acquisition and Ginkgo's cell programming platform. These forward-looking statements generally are identified by the words "believe," "can," "project," "potential," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) volatility in the price of Ginkgo's securities due to a variety of factors, including changes in the competitive and highly regulated industries in which Ginkgo operates and plans to operate, variations in performance across competitors, and changes in laws and regulations affecting Ginkgo's business, (ii) the ability to implement business plans, forecasts, and other expectations, and to identify and realize additional business opportunities, (iii) the risk of downturns in demand for products using synthetic biology, (iv) the unpredictability of the duration of the COVID-19 pandemic and the demand for COVID-19 testing and the commercial viability of our COVID-19 testing business, (v) changes to the biosecurity industry, including due to advancements in technology, emerging competition and evolution in industry demands, standards and regulations, (vi) our ability to realize the expected benefits of merger and acquisition transactions, (vii) the outcome of any legal proceedings against Ginkgo, including as a result of recent acquisitions, (viii) our ability to realize the expected benefits from and the success of our Foundry platform programs, (ix) our ability to successfully develop engineered cells, bioprocesses, data packages or other deliverables, and (x) the product development or commercialization success of our customers. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the "Risk Factors" section of Ginkgo's annual report on Form 10-K filed with the U.S. Securities and Exchange Commission (the "SEC") on March 13, 2023 and other documents filed by Ginkgo from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and Ginkgo assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. Ginkgo does not give any assurance that it will achieve its expectations.
GINKGO BIOWORKS INVESTOR CONTACT:[emailprotected]
GINKGO BIOWORKS MEDIA CONTACT:[emailprotected]
SOURCE Ginkgo Bioworks
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Ginkgo Bioworks Strengthens End-to-End R&D Capabilities in Gene ... - PR Newswire
W&L Engineering Professor Publishes Articles in Two Renowned … – The Columns
By Emily InnesApril 4, 2023
Jon Erickson, professor of engineering at Washington and Lee University, recently published two papers regarding advances in non-invasive gastrointestinal electrical mapping techniques.
The first paper, Validation of noninvasive body-surface gastric mapping for detecting gastric slow-wave spatiotemporal features by simultaneous serosal mapping in porcine, was featured on the cover of the October 2022 issue of The American Journal of Physiology. The second paper, co-authored with Emily Hassid 22 and Elen Stepanyan 22, is titled Comparison of dry and wet electrodes for detecting gastrointestinal activity patterns from body surface electrical recordings and was published in the Annals of Biomedical Engineering in January 2023.
Erickson is an expert in the field of signal processing with applications to gastrointestinal motility. Validation of noninvasive body-surface gastric mapping was written in collaboration with the Auckland Bioengineering Institute at the University of Auckland, New Zealand. Comparison of dry and wet electrodes stems from research conducted at W&L.
I feel very fortunate to have worked with such an exceptional group of surgeons, doctors, and biomedical engineers as well as outstanding undergraduate research students during this process, Erickson said. With a multidisciplinary team, everyone brings their own angles and backgrounds that are crucial to make projects like this work.
The purpose of Ericksons research is to develop non-invasive biomedical tools to monitor motility of the stomach and colon, which may facilitate the diagnosis and phenotyping of gastrointestinal abnormalities. When Erickson began collaborating with the Auckland Bioengineering Institute in 2009, very little was known about the electrical conduction system of the stomach. Over the course of a decade, the research team developed the instruments, technology, and algorithms to successfully detect the electrical waves that move through the stomach, first using surgically implanted electrodes and then with non-invasive electrode arrays placed on the skin surface like a big band-aid. Ericksons primary role in the project was developing the signal processing techniques to pluck out the microvolt-level signals generated internally by the stomachs electrical waves.
The next phase of research, explored in Comparison of dry and wet electrodes, addressed the time limits on studies because of peoples potential sensitivity to the wet electrodes. The study found that dry electrodes are just as effective at recording gastrointestinal electrical signals, which opens the possibility of being able to study gastrointestinal activity over multiple days, instead of just in three- to four-hour increments. W&L students made valuable contributions to designing and conducting the study with human subjects, as well as providing unique insights during the analysis phase.
Its exciting to work on something thats brand new, and the student insights are so important, Erickson said. It has been a delight to work with students who are deeply engaged with the research and helping pioneer this field. Their roles have been crucial to our recent contributions and collective success, and it is very rewarding to see their skill and confidence rapidly grow in the lab.
I was delighted to have so many students interested and deeply engaged with the research. Their roles have been crucial to making this work, and I hope theyve had a good experience with it, too.
Ericksons collaboration with students is representative of the hands-on and personalized education W&L provides. In addition to conducting real-world research, they also participated in the academic journal review and publication process. Both Hassid and Stepanyan have carried their research experience to postgraduate opportunities, with Hassid pursuing a masters degree in chemical engineering at Columbia University and Stepanyan pursuing a masters degree in engineering and management at Dartmouth University.
For Erickson, the next step in this ongoing research project is to begin conducting overnight studies of the gastrointestinal system using dry electrodes and continue advancing the diagnostic capabilities of the technology.
In the near future, we plan to apply this technology to compare and contrast motility patterns in healthy people versus those with a known gastrointestinal abnormality. This is a magical moment in the research field because we finally have the research tools in hand to attempt this study for the first time, Erickson said.
Erickson joined the W&L faculty in 2009 and currently serves as the faculty advisor for the Engineering Community Development club on campus. He received his bachelors degree in physics from Harvey Mudd College and his doctorate in bioengineering from the California Institute of Technology.
If you know a W&L faculty member who has done great, accolade-worthy things, tell us about them! Nominate them for an accolade.
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W&L Engineering Professor Publishes Articles in Two Renowned ... - The Columns
The tale of the ‘ubiquitous’ Stanford Bunny | Stanford University … – Stanford University
In the early 1990s, Stanford professor Marc Levoy and his postdoc, Greg Turk, created the worlds first seamless 3D computer model of a complex object using a range-finding laser scanner. Their object of choice, a terra cotta garden decoration, is now known worldwide as The Stanford Bunny. Computer graphics researchers still use it today. Approaching Easter, we talked to Levoy about what has kept his bunny going even three decades later.
I was a new professor at Stanford. Three-dimensional scanning seemed like an interesting problem, trying to get the shape of an object accurately recorded in a computer. There were scanners at the time that could do some modest range scanning like the front of your face or one that could go completely around you and build a crude model of the surface of an object, but not a complete one, with a top and a bottom and interstices and all that. My postdoc at the time, Greg Turk, and some grad students started to work on this. Its hard to scan an object all at once, so you do it in parts, little meshes, like pieces of fabric, from all around the object. Greg created an algorithm called Zipper that could take a bunch of these meshes and stitch them together to create a seamless, three-dimensional model. We needed a test object. It was around Eastertime, and Greg was out shopping and saw this bunny on a store shelf a terra cotta garden sculpture. It was about the right size. So we scanned it. It was the first model of its kind. It became a popular computer graphics model for people to render on to add fur, or melt, or break, or whatever you can imagine doing to a 3D object.
It was the first detailed polygon mesh model of a very complicated object with lots of little nooks, crannies, and crevices. There had been models of complicated stuff before, but it was all built by hand airplanes and things like that. The idea of just taking an object, sticking it on a platter, and being able to scan it more-or-less automatically and produce a model was new. We put the data online and we made it freely available. It just became ubiquitous; one of the standard models for computer graphics researchers to practice on. If you page through the proceedings of any computer graphics conference today, maybe a third of the papers use the Stanford Bunny. Just Google Stanford Bunny. Youll see.
The bunny replaced what was the iconic computer graphics model, the Utah Teapot. The Computer History Museum approached me a while ago wanting to put the bunny in their museum. So theres a spot for it next to the Utah Teapot, but not yet. The original is still in my office at Stanford. One of the reasons the bunny is popular is because theres no IP associated with it. It was just a simple garden decoration, and anybody could just do anything with it. Its also kind of innocuous, not a religious icon that people could desecrate. And its just the right size to do a lot of experiments on. It just became really popular. Its fun to see the stuff people have done with it. Adding fur. The breakages. The textures.
A lot of people think its LIDAR, the technology used in autonomous vehicles, that measures distance using time of flight how quickly a laser light bounces back to a sensor after striking an object. The technology we used was different. The laser and the sensor are separate, allowing you to triangulate distance like a range finder. The problem was, at the time you could only do one side of an object or a specific area, not an entire object. What we brought to the table were the algorithms for combining multiple scans to make a seamless object. We scanned the bunny all over the place and created mathematical triangles between the measurements. Gregs algorithm was able to match up the edges of these meshes and stitch them together or zip them, as he called it, hence the name Zipper. Those triangles represent the surface of the object and animators can use the data to render pictures. There are exactly 69,451 triangles making up the Stanford Bunny.
Yes, there were several projects after that and some very sophisticated models of very complicated objects. The best known is probably the Digital Michelangelo project where we traveled to Florence to scan Michelangelos David in situ. Our model of the David has a billion polygons which is a lot. That required many, many sweeps, but used a more complicated laser scanner. Our approach not the bunny per se was used quite a bit in the entertainment industry. We made models for Industrial Light & Magic in the making of Star Wars: Episode I The Phantom Menace. We scanned their models in our lab. That was kind of a dramatic day at Stanford where they came in this van with these sealed boxes. They didnt want anyone getting a sneak peek. We had to disconnect our computers in the graphics lab from the internet. We had curtains across all the doorways. They put burly guards at the entrances. And, for a whole day, we scanned their models of various objects and creatures for The Phantom Menace. Then, we gave them a copy of the disk and they watched while we wrote zeros over our data, and that was that.
Related:Marc Levoy, VMware Founders Professor of Computer Science, Emeritus
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The tale of the 'ubiquitous' Stanford Bunny | Stanford University ... - Stanford University
National structural engineering firm breaks into U.S. – Construction Canada
Stephan Kordt, founder of Kordt Engineering Group, is now serving as the president of U.S. operations with RJC Engineers. Photo courtesy RJC Engineers.
Operating from 14 locations in Canada and specializing in structural engineering, the design consultant, RJC Engineers (RJC), has acquired the U.S. firm, Kordt Engineering Group (KEG) from the latters Las Vegas and Reno, Nevada, offices.
The move will help RJC gain a foothold all over North America and endow its experience, capabilities, and depth of services to help KEG better cater to their clients. Both firms will continue offering services in structural, facade, structural glass engineering, and more.
KEG has clients in structural engineering all over North America and Europe, in various domains, from commercial buildings sector to landmark structures. The firm is well-known for its exceptional client service and both firms cultures match in relation to prioritising their employees and customers.
Stephan Kordt, KEGs founder, has been appointed as the president of U.S. operations at RJC. As a reputable engineer and reliable leader, Kordt has earned recognition for completing high-quality projects under strict time constraints. His extensive technical expertise, industry connections, and skill in devising sophisticated and fitting structural solutions have made him a highly sought-after professional in the U.S. Kordts notable undertakings comprise The Watermark, Project 63, Crystals at CityCenter, Golden Gate Hotel & Casino expansion, Venetian Casino Resort, Venezia Hotel Tower, and the World Market Center.
RJC is excited to further establish ourselves in the U.S. through acquiring KEG. Our firms and people have worked together for over a decade and share a history of successfully delivering projects throughout the U.S., says Mike Moffatt, executive principal of RJC. Our strategic expansion into the U.S. allows RJC to bring its expertise in many building sectors and service offerings to a broader client base.
We are thrilled to join forces with RJC and look forward to working with an even wider group of clients across the U.S., says Kordt. We will continue to deliver the high-quality client service and innovative structural engineering solutions we are known for, while bringing the expanded depth of expertise, resources, and services offerings now available to us as part of RJC.
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National structural engineering firm breaks into U.S. - Construction Canada
James Webb peers even further back in time to reveal most distant … – Interesting Engineering
James Webb observes the oldest galaxies ever seen
The two new papers present analyses of redshift light observed by James Webb. Redshift light refers to light that has been traveling for such a long time that the expansion of the universe has stretched its wavelength into the red part of the electromagnetic spectrum.
From early on in its scientific operations, James Webb has used this method to break records by observing the most ancient galaxies ever observed.
For the new observations, the scientists measured the redshift of the light observed by Webb and found that it was at the extreme end of the spectrum, stretched all the way into the infrared end of the spectrum.
Webb's spectra analyses.
The analyses show that the galaxies present in the new observations existed when the universe was less than 350 million years old.
Webb used its near-infrared camera (NIRCam) and Near-Infrared Spectrograph (NIRSpec) instrument to detect a total of four new ancient galaxies. These have been dubbed JADES-GS-z100, JADES-GS-z110, JADES-GS-z120, and JADES-GS-z130. JADES stands for "JWST Advanced Deep Extragalactic Survey."
After measuring the redshift of the ancient galaxies, the astronomers confirmed their findings using spectroscopy.
"It was crucial to prove that these galaxies do, indeed, inhabit the early universe. It's very possible for closer galaxies to masquerade as very distant galaxies," Emma Curtis-Lake, a co-author of one of the new studies and an astronomer at the University of Hertfordshire in England explained in ESAs press statement.
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James Webb peers even further back in time to reveal most distant ... - Interesting Engineering
UI College of Engineering lab in Coralville destroyed by tornado – UI The Daily Iowan
The research laboratory, used by the UI College of Engineering and located on James Street in Coralville, became unusable as a result of storms that came through the area on March 31.
A University of Iowa research lab in Coralville used by the College of Engineering was destroyed by the March 31 storm that caused damage across the city, the university announced Tuesday.
In an IowaNow article, the UI stated that the research lab, located at 2421 James St. in Coralville, will not be repaired and has to be completely rebuilt.
The building that housed the lab was built in 2003 and is one of several in Johnson County that were destroyed in the storm. The lab was unoccupied at the time and no one was injured, it states.
Harriet Nembhard, the dean of the UI College of Engineering, said in the article that she is devastated about the destruction caused to the facility, but was relieved that no one was hurt in the storm.
Engineers are resilient. We will rebuild, and we will continue our critically important research, Nembhard said in the article.
Both residential and commercial properties were damaged or destroyed by the tornado March 31.
Coralville was one of multiple areas hit that night, along with the nearby communities of Hills, Solon, North Liberty, West Branch, and Tiffin. The National Weather Service estimates more than 20 tornadoes tore across Iowa Friday.
Johnson County is currently under a tornado watch until 10 p.m. Tuesday.
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UI College of Engineering lab in Coralville destroyed by tornado - UI The Daily Iowan
Hell, prayer rug and Turkish opposition’s reverse engineering efforts | Daily Sabah – Daily Sabah
Political parties in Trkiye are working hard to finalize their candidate lists by the April 9 deadline. The relevant committees probably find it more difficult to select candidates today than ever. The already-complex selection process is further complicated by electoral alliances producing joint lists in certain districts and trying to predict how those decisions may influence the allocation of parliamentary seats.
Although the campaign period is already underway, presidential candidates largely refrain from picking rhetorical fights in the holy month of Ramadan.
President Recep Tayyip Erdoans schedule features iftar dinners, groundbreaking ceremonies in the earthquake-hit zone, and the inauguration of significant projects. In this sense, the incumbent keeps reminding voters that he distinguishes himself from the rest through his history of public service, projects, and actions.
Meanwhile, the main opposition Republican Peoples Party (CHP) Chairperson Kemal Kldarolu, having received the opposition blocs endorsement, attempts to replace his combative attitude with a more inclusive approach. Yet some pro-CHP media personalities continue to threaten to hold the ruling Justice and Development Party (AK Party) circles accountable and put them on trial. In this sense, what we see is reminiscent of the 2019 municipal elections. The CHP leadership claims to welcome everyone, but it continues to fuel polarization in an attempt to consolidate its base. As a result, it wont be surprising to encounter more heated debates after April 9, especially after Ramadan.
What caught my attention in the current election cycle is the Hell, prayer rug, and reverse engineering, which support certain politicians, to make radical and essentialist distinctions and accusations. Let me elaborate: The essentialist, extreme, and alienating tone that pro-opposition commentators, academics, and media personalities have adopted to "unite the opposition and mobilize voters have become a cause of concern. For example, the Good Party (IP) Chairperson Meral Akeners metaphorical stoning upon leaving the opposition bloc and Muharrem nces ongoing treatment over his decision to contest the presidential election reflect the massive anger that the ultra-secularist opposition has accumulated. By contrast, the Felicity Party (SP), the Democracy and Progress Party (DEVA), and the Future Party (GP) did not encounter a similar reaction from conservatives for joining the CHP-dominated opposition bloc, also known as the "table for six. In other words, Trkiyes conservatives some like to criticize for supposedly being obedient and believing in pre-determinism have been reflecting on the countrys issues more rationally and with greater common sense than the ultra-secularists.
Domestic and international audiences agree that the May 14 elections are critically important. One must ask, however, what to make of the ultra-secularist rage that causes them to "lynch fellow members of the opposition as "separatists? How does referring to the next elections as "the last" makes sense? What kind of a metaphor has a former diplomat used by claiming they will "close the gates of hell by changing the government?
I doubt that labeling the AK Party government in such ways could influence voters. Equating the current situation with "hell is no less tragicomical than Kemal Kldarolu clumsily reciting a Quranic verse at an iftar dinner hosted by the Felicity Party.
Has the main opposition party already exhausted the discourse of one-man rule? Is that why they exploit religious symbols and concepts at the expense of the AK Party and conservatives? That ultra-secularist reverse engineering attempt shall fail as soon as the CHP chairperson steps on a prayer rug with his shoes.
The Peoples and Nation Alliance represent two different visions for Trkiyes future. It is the job of opinion-makers to compare and interpret their respective policy papers, statements, and campaign pledges.
Why would anyone subject the country to an essentialist choice between power and morality? In an attempt to support Kldarolu, some left-wing academics have been portraying the government as "evil and the opposition as "good which suffers from essentialist radicalism. Their actions have long exceeded the limits of the all-too-familiar divide between "us and "them in politics. Are we to believe that allying with the Free Cause Party (HDA-PAR) and the New Welfare Party (Yeniden Refah Partisi) amounts to "misogyny, but joining forces with the Peoples' Democratic Party (HDP) and receiving PKKs endorsement is about "working for people with problems in Trkiye?
That academics assess the AK Party experience from an essentialist and radical standpoint, which goes beyond politicization, is a source of concern for the entire country.
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Hell, prayer rug and Turkish opposition's reverse engineering efforts | Daily Sabah - Daily Sabah
Architectural, Engineering Consultants And Related Services Global Market Report 2023: Increasing Investments in Smart Cities to Fuel $1.4 Trillion…
DUBLIN, April 4, 2023 /PRNewswire/ -- The "Architectural, Engineering Consultants And Related Services Global Market Opportunities And Strategies To 2032" report has been added to ResearchAndMarkets.com's offering.
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The architectural, engineering consultants and related services market reached a value of nearly $1,440.87 billion in 2022, having grown at a compound annual growth rate (CAGR) of 3.1% since 2017. The market is expected to grow from $1,440.87 billion in 2022 to $1,771.27 billion in 2027 at a rate of 4.2%. The market is then expected to grow at a CAGR of 5.4% from 2027 and reach $2,302.93 billion in 2032.
Growth in the historic period in the architectural, engineering consultants and related services market resulted from rise in demand for environmentally safe and certified buildings, strong economic growth in emerging markets, rise in construction activity, globalization and government subsidies and funding. The market was restrained by outbreak of coronavirus disease (covid-19), challenges due to stringent regulation, rising material costs and geo-political tensions.
Going forward, faster economic growth, increasing investment in smart cities, increasing infrastructure development expenditure by governments, and green construction will drive the market in future. Factors that could hinder the growth of the market in the future include Russia Ukraine war and lack of skilled workers.
The architectural, engineering consultants and related services market is segmented by type into engineering services, architectural services, surveying & mapping services, geophysical services, laboratory testing services and building inspection services and drafting services. The engineering services segment was the largest segment of the engineering services market segmented by type, accounting for 76.2% of the total in 2022. Going forward, the architectural services segment is expected to be the fastest growing segment in the architectural, engineering consultants and related services market segmented by type, at a CAGR of 6.7% during 2022-2027.
The engineering services market is segmented by type into civil engineering services, electrical engineering services, mechanical engineering services and other engineering services. The civil engineering services segment was the largest segment of the engineering services market segmented by type, accounting for 51.0% of the total in 2022. Going forward, the other engineering services segment is expected to be the fastest growing segment in the engineering services market segmented by type, at a CAGR of 5.0% during 2022-2027.
The architectural services market is segmented by type into landscape architectural services and building and structural architectural services. The building and structural architectural services segment was the largest segment of the architectural services market segmented by type, accounting for 90.2% of the total in 2022. Going forward, the building and structural architectural services segment is expected to be the fastest growing segment in the architectural services market segmented by type, at a CAGR of 6.9% during 2022-2027.
The geophysical services market is segmented by type into geophysical data collection; geophysical data sales; integrated geophysical services and other geophysical services. The geophysical data collection segment was the largest segment of the geophysical services market segmented by type, accounting for 51.6% of the total in 2022. Going forward, the other geophysical services segment is expected to be the fastest growing segment in the geophysical services market segmented by type, at a CAGR of 5.6% during 2022-2027.
The architectural, engineering consultants and related services market is also segmented by application into road, rail, port, airport, pipeline, power, other applications. The other applications segment was the largest segment of the architectural, engineering consultants and related services market segmented by application, accounting for 49.7% of the total in 2022. Going forward, airport segment is expected to be the fastest growing segment in the architectural, engineering consultants and related services market segmented by application, at a CAGR of 6.3% during 2022-2027.
The architectural, engineering consultants and related services market is also segmented by service provider into large enterprise, and small and medium enterprise. The large enterprise segment was the largest segment of the architectural, engineering consultants and related services market segmented by service provider, accounting for 70.0% of the total in 2022. Going forward, small and medium enterprise segment is expected to be the fastest growing segment in the architectural, engineering consultants and related services market segmented by service provider, at a CAGR of 4.3% during 2022-2027.
Western Europe was the largest region in the architectural, engineering consultants and related services market, accounting for 30.8% of the total in 2022. It was followed by North America, and then the other regions. Going forward, the fastest-growing regions in the architectural, engineering consultants and related services market will be Middle East, and, South America where growth will be at CAGRs of 13.7% and 13.7% respectively. These will be followed by Africa, and, Asia-Pacific where the markets are expected to grow at CAGRs of 6.5% and 4.8% respectively.
The global architectural, engineering, and related services market is fragmented, with a large number of small players. The top ten competitors in the market made up to 2.63% of the total market in 2021. This can be due to the existence of a number of local players in the market serving customers in particular geographies. Downer EDI Limited was the largest competitor with 0.60% share of the market, followed by WSP Global Inc. with 0.43%, John Wood Group PLC with 0.34%, Jacobs Engineering Group, Inc. with 0.31%, Fluor Corporation with 0.18%, Babcock International with 0.18%, KBR, Inc. with 0.16%, WorleyParsons Limited with 0.15%, Stantec with 0.14%, and Bechtel Corporation with 0.13%.
The top opportunities in the architectural, engineering consultants and related services market segmented by type will arise in engineering services segment, which will gain $214.0 billion of global annual sales by 2027. The top opportunities in the engineering services market segmented by type will arise in civil engineering services segment, which will gain $88.28 billion of global annual sales by 2027. The top opportunities in the architectural services market segmented by type will arise in building and structural architectural services segment, which will gain $64.14 billion of global annual sales by 2027.
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The top opportunities in the geophysical services market segmented by type will arise in geophysical data collection segment, which will gain $0.74 billion of global annual sales by 2027. The top opportunities in the architectural, engineering consultants and related services market segmented by application will arise in other applications segment, which will gain $113.76 billion of global annual sales by 2027. The top opportunities in the architectural, engineering consultants and related services market segmented by service provider will arise in small and medium enterprise segment, which will gain $230.43 billion of global annual sales by 2027. The architectural, engineering consultants and related services market size will gain the most in the Chinaat $54.33 billion.
Market-trend-based strategies for the architectural, engineering consultants and related services market include rising virtual architectural firms, move towards carbon-neutral buildings, metaverse architecture, adopting artificial intelligence, use of augmented reality, sustainable architecture, modular design for flexibility and use of Computer-Aided Design (CAD).
The report covers the following chapters
Brief introduction to the segmentations covered in the market, definitions and explanations about the architectural, engineering consultants, and related services market.
The product analysis section of the report describes the leading products in the architectural, engineering consultants, and related services market along with key features and differentiators for those products.
The supply chain section of the report defines and explains the key players in the architectural, engineering consultants, and related services industry supply chain.
This chapter covers recent customers' trends/preferences in the global architectural, engineering consultants, and related services market.
Highlights the major trends shaping the global architectural, engineering consultants, and related services market. This section also highlights likely future developments in the market.
Global historic (2017-2022) and forecast (2022-2027), and (2027-2032) market values, and drivers and restraints that support and control the growth of the market in the historic and forecast periods.
Historic (2017-2022) and forecast (2022-2027), and (2027-2032) market values and growth and market share comparison by region.
Contains the market values (2017-2032) and analysis for each segment by type, by industry and by application in the market.
Regional market size (2022), historic (2017-2022) and forecast (2022-2027), and (2027-2032) market values, and growth and market share comparison of countries within the region. This report includes information on the regions Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa and major countries within each region.
Details on the competitive landscape of the market, estimated market shares and company profiles of the leading players.
Information on recent mergers and acquisitions in the market covered in the report. This section gives key financial details of mergers and acquisitions, which have shaped the market in recent years.
Describes market opportunities and strategies based on findings of the research, with information on growth opportunities across countries, segments and strategies to be followed in those markets.
Includes recommendations for architectural, engineering consultants, and related services providers in terms of product/service offerings geographic expansion, marketing strategies and target groups.
This chapter describes the parent design, research, promotional and consulting services market of which the architectural, engineering consultants, and related services market is a segment. This chapter includes the global parent market 2017-27 values, and regional and country analyses for the parent market.
This section includes details on the NAICS codes covered, abbreviations and currencies codes used in this report.
A selection of companies mentioned in this report includes
For more information about this report visit https://www.researchandmarkets.com/r/xqfq15
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Supporting young women in STEM with the Amazon Future … – About Amazon.co.uk
Applications are still open for this years Amazon Future Engineer bursary scheme. The national programme is an opportunity for women students from low-income households, who plan to study computer science or related engineering courses at university, to get financial and mentoring support to build their future careers in STEM. Applications close at 5pm on 17 April 2023.
Women are still significantly underrepresented in engineering and technology in higher education. UCAS data on university application and acceptance figures for the 2022 cycle highlighted that women represent just 19% of accepted applications to computing and engineering degrees.
These bursaries aim to help address underrepresentation and accelerate the rate of progress. They will provide successful women applicants with a financial support package worth up to 20,000 to cover expenses related to attending university, including tuition fees or accommodation and living costs.
Last year, Amazon and the Royal Academy of Engineering expanded the Amazon Future Engineer bursary scheme to support 31 women students to study at UK universities. Read some of their inspiring stories below.
Beatriz Gavina, University of Nottingham, Electrical & Electronic Engineering
Gaming enthusiast Beatriz has always loved physics, and after a chance career chat over Facetime with a professor at MIT, she realised the more practical application of the subject was what she loved the most.
I always loved the part of physics where youre in the lab, I like building things, Ive even built my own PC a couple of years ago and it was so much fun. Because of this, and after a great career chat I managed to have with a professor from MIT, I realised engineering was the path for me.
After finishing her degree, Beatriz wants to continue her education and get a masters, perhaps even a PhD and go into the field of quantum technology. She hopes to do something that makes a positive impact in the world.
I have a notebook where I write down all my ideas and concepts for futuristic gadgets. When Im accomplished enough in my field, Id love to build one of these. If I could work on something that slowed climate change or helped with renewable energy that would be my dream.
Beatriz is already part of the Women and Engineering Society at Nottingham University where she studies and is keen to push for better representation in the engineering industries.
I didnt just apply for the bursary, I applied for all the good stuff that comes with it. Im excited about the network that Amazon Future Engineer opens for women. Internships and work placements are really important in engineering and the programme encourages and supports that.
Aneesah Khan, University of Cambridge, Computer Science
East London born Aneesah always had an interest in technology, but really unlocked her passion for computer science in sixth form.
I started to apply myself and was challenged to study much harder. Its funny because in year 10 our school took us to visit Clare College at Cambridge University, and thats where I study computer science now!
Its important to me that I do something positive that can make a change, whether its using data to find correlations between drugs and diseases or increasing accessibility to healthcare or education.
Aneesah advocates for other women and girls getting involved in STEM: Entering the STEM field can be intimidating at first. I thought I wouldn't see anyone that looked like me or talked like me, but there is a lot of support available, especially through the bursary.
With the support of the Amazon bursary, I can access hardware required for my course and improve my knowledge with further research that might otherwise be quite costly. Maybe most importantly, the bursary also provides a network and a community feeling that is really important for women and girls entering STEM.
Farheen Mehmood, Newcastle University, Computer Science
Originally from Pakistan, Farheen moved to Newcastle at the age of six and soon discovered her passion for computer science.
Ive been in love with the subject ever since I discovered it. Computing sucked me in like a black hole!
At school, Farheen had her first glimpse of programming through Scratch and then studied computer science at GCSE and A-Level, learning Python at school and teaching herself Java, both of which are programming languages.
I found it fascinating that I could make something of true value and meaning that could help so many people in the world, all while sitting in my living room.
Farheens potential has been recognised by the Amazon Future Engineer Bursary, which will support her during her first year of Computer Science at Newcastle University.
Farheen credits her family as her inspiration, particularly her late mother: I aspire to become like my mum one day. I want to be both passionate about my field and able to provide for my family and educate my kids.
Farheen has big plans for the future, explaining, I want to climb the ranks in one of the top five tech companies and my work to level the playing field for others.
Ilenia Maietta, Queen Mary University, Computer Science
Originally from Avella, a small town near the coast in Italy, Ilenia discovered computer science by chance and has fallen in love with the subject, she is now attending Queen Mary University aged 17.
I got into computer science because it was a subject that I didnt have the chance to study while living in Italy, so I wanted to try it out. When I was in the classes, I realised that this was something that I would love to pursue!
When I was living in southern Italy, there wasnt a lot of access to STEM subjects in my small town. My parents wanted to move so that my sister and I would have more opportunities to study, and Ive always wanted to live in London.
When we did move to London I ended up attending an engineering school. It was life-changing, suddenly I was in classes working on robotics and computing and all these amazing STEM subjects I had never heard of before.
I find cybersecurity and digital forensics fascinating. I think if I was going to pursue a master's or a doctorate, Id probably focus on those subjects.
When I found out my application for the bursary was successful, I couldnt believe it. It's been a huge weight off my shoulders, and its really helped with stuff like books and transport to uni!
Nazma Mulla, University of Glasgow, Computer Science
Growing up in Preston, Lancashire, Nazma knew from a young age that she wanted to study computer science. Inspired by her older brother Jamal, who would come home from university and speak about what he had been learning, she decided at age 14 that she wanted to do the same.
Now in her first year at the University of Glasgow, she is studying Computer Science along with Philosophy and Statistics. She loves that this is helping her prepare her for a dream career in Artificial Intelligence (AI). Nazma is laser focused on going straight into a master's course then a PhD to fulfil her AI career dream and is grateful that the bursary means she wont have to worry about finding a part-time job.
Finding out shed been successful in the bursary application, she was overjoyed: I remember running down the stairs to tell my family. Now I dont have to worry about funding my degree and can put 100% of my focus into academia.
She hopes to be part of a generation that balances gender disparity in the industry.
I want to improve representation in the academic subject and in the industry. You have to keep putting in the effort and focusing on yourself, I try not to be phased by the fact that Im in a class of mostly male students.
Shes excited that the AFE programme is not just a bursary but will offer her connections and work experience opportunities so that she can begin climbing the career ladder, challenging gender representation along the way.
Find out how to apply to this years Amazon Future Engineer bursary scheme.
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Supporting young women in STEM with the Amazon Future ... - About Amazon.co.uk
Pentagon Launches Classified Program To Reverse-Engineer and … – The Debrief
The Defense Advanced Research Projects Agency, DARPA, recently launched a new classified program to develop transformative tools to rapidly reverse-engineer and exploit vulnerabilities in emerging technologies and commercial cyber-physical systems.
DARPA has not formally announced the new program, and much of the project is expected to be shrouded in secrecy.
However, pre-solicitation documents obtained byThe Debrief reveal the effort will be run out of the DARPAs Microsystems Technology Office under the moniker: Faithful Integrated Reverse-Engineering and Exploitation, or FIRE.
In a late March presentation to potential industry partners, DARPA officials explained that FIRE will focus on vulnerabilities in commonly used cyber-physical systems, such as energy grids, autonomous automobile systems, medical monitoring, or industrial control systems.
The primary goal of FIRE is to develop new ways to quickly find, exploit, and patch vulnerabilities in medium-complexity cyber-physical systems. DARPA notes that the tools developed in FIRE must achieve these goals at an unprecedented pace of at least a month of receiving hardware for analysis.
The FIRE goals are driven by the proliferation of low-cost commercial-off-the-shelf (COTS) components (e.g., sensors, actuators, and algorithms) resulting in diverse classes of CPS including smart meters, medical devices, autonomous vehicles, and industrial control systems to name a few, reads a broad agency announcement issued by DARPA on March 15.
Furthermore, agile development practices have shown that even highly complex systems such as cars can be remotely patched every few weeks. Innovative CPS vulnerability analysis tools and techniques are needed to keep pace with increased system diversity and decreased analysis timelines.
Documents clarify that DARPA is not interested in tools that independently address cyber or physical vulnerabilities. Instead, FIRE is focused on how the composition of hardware, software, and physical components can make technology systems uniquely susceptible to attack.
During the March presentation, DARPA offered a demonstration of the types of cyber-physical system vulnerabilities its interested in by showcasing an example of how to crash a quadcopter using acoustics.
Program officials explained how specific sound frequencies can inject false readings into the micro-electro-mechanical Systems (MEMS) gyroscope of a quadcopter,ultimately destabilizing the drone and causing it to crash.
The scenario used by DARPA is not hypothetical. Research by theKorea Advanced Institute of Science and Technology has demonstrated that a quadcopter drone can be downed by projecting sound frequencies under 30 kHz through a consumer-grade speaker.
With this example, DARPA expects new analysis tools developed in the FIRE program to be able to identify that a quadcopters gyroscope is vulnerable to an acoustic attack; develop ways to exploit that vulnerability (e.g., using speakers to project sound frequencies toward a drone); and ultimately methods for nullifying a quadcopters vulnerability to acoustic attacks.
By taking this holistic approach, FIRE could provide the Department of Defense (DoD) with a new ways to identify and launch disruptive, asymmetric attacks on enemy systems in various sectors, including civil infrastructure, energy, healthcare, transportation, or manufacturing. Simultaneously, this same process can be used to better shore-up U.S. cyber-physical systems from similar threats.
DARPA notes the first step in the analysis process should involve reverse engineering a cyber-physical system by creating an identical digital twin.
With everyday items increasingly integrated with new and emerging technologies, the threat of cyber-physical attacks has become a significant concern.
Pastresearchhas demonstrated it is relatively easy to gain long-distance control, location tracking, or in-cabin audio exfiltration by exploiting vulnerabilities in the electronic control systems found in most modern cars.
Once you have access to a vehicle, you pretty much have access to any part,saidDr. Skanda Vivek, a physicist atGeorgia Gwinnett Collegespecializing in autonomous vehicle control. If you get to one control unit like the entertainment system, for example then with some reverse engineering, you could control the steering wheel.
Industrial control systems, or technologies enabling control, automation, and monitoring in industrial environments like electric plants, manufacturing facilities, and refineries, are mentioned as a key focus area for the FIRE program.
A large portion of DARPAS FIRE presentation was also dedicated to identifying vulnerabilities to maritime industrial controls systems (ICS).
DARPA notes that many modern maritime ICS used for everything from powering a ship to processing wastewater are becoming more intelligent and packed with convenient features that could be potentially exploited by malicious attacks.
Most of the FIRE program is expected to be cloaked in secrecy, and private companies or academic institutions working on the program are required to maintain active security clearances and facilities approved to store classified materials.
DARPA anticipates selecting industry partners and issuing contract awards for the FIRE program to occur by the fall of 2023.
If all goes according to plan, the first set of analysis tools for cyber-physical systems should be delivered by the spring of 2024, with the entire research and development process slated to run through mid-2027.
Tim McMillan is a retired law enforcement executive, investigative reporter and co-founder of The Debrief. His writing typically focuses on defense, national security, the Intelligence Community and topics related to psychology. You can follow Tim on Twitter:@LtTimMcMillan. Tim can be reached by email:tim@thedebrief.orgor through encrypted email:LtTimMcMillan@protonmail.com
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Pentagon Launches Classified Program To Reverse-Engineer and ... - The Debrief