Shares of H.G. Infra Engineering Ltd. hit a record high on Tuesday after its profit rose 37% in the June quarter.

The construction firm's profit increased to Rs 150.4 crore compared to Rs 109.4 crore in the same quarter last fiscal, according to an exchange filing on Monday.

Shares of H.G. Infra Engineering were trading 0.76% higher at Rs 957.45 apiece as of 11:45 a.m., compared to a 0.05% decline in the benchmark NSE Nifty 50. The stock hit an all-time high of 3.97% at Rs 988, the most in one week.

The stock has risen nearly 54.83% year-to-date. The total traded volume so far in the day stood at 4.6 times its 30-day average. The relative strength index was at 68.04.

Fifteen out of the 16 analysts tracking H.G. Infra Engineering maintain a 'buy' rating on the stock, while one recommends a 'hold', according to Bloomberg data. The average of 12-month analyst price targets implies a potential upside of 18.9%.

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H.G. Infra Engineering Shares At Record High As Q1 Profit Jump - BQ Prime

video:Assembly of a closed box by the convective flows. A) Initial position of the rectangular base that catalyzes chemical reaction and generates flows, and four rectangular side panels. Binding beads are shown in orange. B) The first sheet approaches, binds to the base, and is dragged by the flow upward. C) The second sheet approaches, binds to the base, and is dragged upward. D) The third sheet binds to the base, and is dragged upward. E) The four side panels are assembled into an open box. F) The four blue flaps are joined to form a closed lid at the top of the box. view more

Credit: Oleg Shklyaev

PITTSBURGH (July 31, 2023) Automating the construction of three-dimensional structures that are 10s of millimeters in size would revolutionize manufacturing of devices for optical, electrical and biomedical applications. An economical process for constructing such 3D microstructures would be to program the constituent parts to spontaneously come together and build the structures themselves. Driving micron to mesoscale components (roughly between 0.1 to 100 millimeters) to line up and dynamically assemble into the desired structures, however, remains an elusive goal.

Chemical engineering researchers at the University of Pittsburgh Swanson School of Engineering have built upon their previous research to overcome the challenge of designing such properly self-aligning structures by using fluid mechanics, chemo-mechanical processes and a little stickiness.

Their research, Engineering confined fluids to autonomously assemble hierarchical 3D structures, was published in PNAS Nexus (https://doi.org/10.1093/pnasnexus/pgad232). Lead author is Oleg E. Shklyaev, post-doctoral associate with Anna Balazs, Distinguished Professor of Chemical and Petroleum Engineering and the John A. Swanson Chair of Engineering, with former post-doc Abhrajit Laskar.

One of the fundamental challenges in building anything with micron sized building blocks is to get the blocks to robustly organize on their own, with little intervention from external tools, which could interfere with the dynamic self-assembly, Balazs explained. Whats wonderfully brilliant about the system that Oleg designed is that the naturally occurring interplay between the fluid and chemistry performs the work to spontaneously construct a robust system.

Via computer modeling, Shklyaev designed two-dimensional polymeric sheets with one heavier sheet forming the foundation or base, and the other lighter sheets as the construction panels. Sticky bonds are added to specific points on the sheets to act as hinges similar to DNA molecule bonds (A,C, G, T) which are designed to precisely fit together.

The panels are then dropped into a solution and sink to the bottom in random areas of the tank. The addition of a reactant to the solution instigates a catalytic reaction, which generates fluid flows that have velocities both vertical and horizontal to the confining walls. The horizontal flow first moves the sheets together along the chamber floor, and the sticky bonds connect the appropriate panel to the base. Next, the vertical flow lifts the sides of the structure into the upright position,where again the panels are connected via sticky bonds to complete the structure.

This conversion of chemical energy (released from the catalytic reaction) into mechanical action (fluid flow) is an inherent property of the system. Namely, as the catalytic reaction converts reactants into products, it intrinsically produces density or concentration gradients in the solution. The gradients, in turn, generate a force that acts on the fluid and triggers the flow. The flow acts like helping hands to assemble the structure, Shklyaev explained. Through chemistry, you can engineer the spatially and temporally varying patterns that emerge in the flow, and thereby tailor the work done by these hands, which also initiate the cascade of events that leads to building a regular tetrahedron, cube, or similar structure. In principle, the sticky bonds on the panels can involve strands of DNA; the complementarity of DNA strands enables the bonds to be highly selective and recognize the regions to which it should stick.

By engineering the fluid flows, Shklyaev could drive the self-organization of a cube and the closing of the cubes lid, so that the entire structure resembled a takeout box. The chemically generated fluid flow acting on the panels (through mechanisms knows as solutal buoyancy and diffusioosmosis) eventually reaches a dynamic steady state as it completes the assembly of the object, which could later be removed out of the fluid and maintain its integrity.

To further illustrate the potential of the fluidic machinery, the tops of each panel were decorated with long whiskers. As the panels fold upward and the whiskers extend into the fluid flow, the resulting forces drive the whiskers to rotate, much like moving propellers. Sticky bonds could be added to the whiskers to attract bacteria or other materials that need to be removed from the system.

The use of chemical reactions to tailor the flow to act as a mechanical tool has not been broadly applied in man-made systems, but is particularly valuable since the fluid flow performs the necessary work and replaces complicated machinery, Balazs said. "The process is scalable; multiple structures with different shapes can be formed at one time.

By providing these guidelines to experimentalists, we can automate manufacturing processes since the structure formation is driven by the dynamic self-assembly of the components. The resulting structures can be used for medical applications since the processes typically involve water, which provides a biologically friendly environment.

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Computational simulation/modeling

Not applicable

ngineering confined fluids to autonomously assemble hierarchical 3D structures

24-Jul-2023

The authors declare no competing interest.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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A paper published today in Nature Metabolism has described a method of genetically engineering cells to respond to electrical stimuli, allowing for on-demand gene expression.

Despite its futuristic outlook, this line of research is built upon previous work. The idea of an implantable gene switch to command cells in order to deliver valuable compounds into the human body is not new. The authors of this paper cite longstanding work showing that gene switches can be developed to respond to antibiotics [1] or other drugs, and the antibiotic doxycycline is used regularly for this purpose in mouse models. More recently, researchers have worked on cells that control their output based on green light [2], radio waves [3], or heat [4].

However, these mechanisms have their problems. A gene trigger that operates in response to a chemical compound requires that compound to have stable, controllable biological availability [5]. If it relies on any wavelength of electromagnetic radiation, that process may be triggered by mistake or require intense energy to function [3].

Therefore, these researchers decided to focus on developing triggers that respond to electricity itself. While previous work in this area has relied on battery-powered implantable devices that are poorly suited for therapeutic use [6], this team built on a process that naturally exists.

Reactive oxygen species (ROS) have a well-deserved bad reputation in the world of longevity, as they are associated with mitochondrial dysfunction and age-related deterioration. However, applying low-voltage direct current can induce production of ROS that is well below dangerous levels [6]. While normal cells are not particularly sensitive to such low levels of ROS, these researchers found a way to hypersensitize engineered cells to respond to them. They call their development DC-actuated regulation technology (DART).

In their initial testing apparatus, the researchers engineered cells to produce the glycoprotein SEAP when exposed to electricity. They placed plates of these cells in a medium that was exposed to electrical current between two electrodes. Short-term, low-power DC current was found to have no affect on cell viability. Inducing current for 30 seconds at a time was harmful, but the researchers ascribe this fact to gas and pH changes occurring at the electrodes.

The approach appeared to work. The engineered cells produced six times more SEAP after they had been exposed to electricity, whether at 10 volts for 15 seconds or 5 volts for 20 seconds.

These results were broadly recapitulated through multiple experiments, as the researchers used 5V DC on different types of engineered cells in different patterns for different lengths of time. Some cell lines responded much better to DART than others.

Further experiments showed that lower voltages over longer time periods, and slightly higher voltages over shorter time periods, could accomplish similar results.

These encouraging results led to an equally encouraging in vivo test. A mouse model of diabetes had received encapsulated cells that express insulin in response to electricity, and their blood glucose was monitored. Unstimulated, these mice still had high blood glucose, and animals that were electrically stimulated far from the target cells also did not respond. Only the diabetic mice that had their cells directly stimulated had blood glucose levels akin to wild-type mice.

In total, these results are highly encouraging for drug deployment. If time- and release-dependent drugs such as insulin can be reliably triggered through low-voltage electricity, it may obviate the need for regular injections of these drugs. Even an automatic system could, in theory, detect high blood glucose and respond with insulin-producing pulses.

However, the reliance on ROS as a delivery mechanism is concerning in a specific way. If these cells, themselves, are allowed to age or otherwise express additional ROS outside of electrical stimulation, this could lead to dangerous situations. Therefore, if DART is ever deployed in human beings, the implanted cells will need to be closely monitored.

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[1] Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A., & Collins, J. J. (2007). A common mechanism of cellular death induced by bactericidal antibiotics. Cell, 130(5), 797-810.

[2] Mansouri, M., Hussherr, M. D., Strittmatter, T., Buchmann, P., Xue, S., Camenisch, G., & Fussenegger, M. (2021). Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes. Nature Communications, 12(1), 3388.

[3] Stanley, S. A., Gagner, J. E., Damanpour, S., Yoshida, M., Dordick, J. S., & Friedman, J. M. (2012). Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice. Science, 336(6081), 604-608.

[4] Stefanov, B. A., Teixeira, A. P., Mansouri, M., Bertschi, A., Krawczyk, K., Hamri, G. C. E., & Fussenegger, M. (2021). Genetically encoded protein thermometer enables precise electrothermal control of transgene expression. Advanced Science, 8(21), 2101813.

[5] Shao, J., Xue, S., Yu, G., Yu, Y., Yang, X., Bai, Y., & Ye, H. (2017). Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice. Science translational medicine, 9(387), eaal2298.

[6] Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology, 39(1), 44-84.

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Genetically Engineering Cells to Respond to Electricity - Lifespan.io News

Nestled in a picturesque green campus, HITAM inspires a love for learning while promoting sustainable practices. Their IGBC certified green building reflects the colleges commitment to environmental consciousness and sustainable development.

At HITAM, the institution believes in the power of hands-on learning. Their innovative approach ensures that students actively engage in their education, developing the practical skills and knowledge necessary to thrive in the ever-evolving technological landscape. The college is led by a team of highly qualified and experienced faculty members, striving to create a stimulating environment that enables creativity, critical thinking, and problem-solving abilities.

HITAM boasts state-of-the-art facilities, including well-equipped labs, libraries, and workshops, providing students with the tools they need to excel. In collaboration with industry leaders, HITAM has established an AR/VR Lab. Through the Cognizant/ICT Academy Centre of Excellence, they have trained and certified over 120 girls in AWS, empowering them with sought-after skills in the industry.

Research and innovation are at the core of HITAMs educational philosophy. The college houses research centers in Robotics, IoT, AI/ML, and a Multidisciplinary Emerging Technologies Application Centre (META Centre), encouraging students and faculty to pursue groundbreaking research projects and publish papers in leading academic journals. Their commitment to excellence has resulted in patents won by students, along with research internships at renowned institutions like Nanyang Technological University, Singapore.

But it doesnt stop there. HITAM offers its students a vibrant campus life, nurturing holistic development and unleashing their true potential. A range of extracurricular activities and clubs, including the Google Developer Student Club, HITAM Toastmasters Club, Literary Club, Hackathon Club, etc., provide opportunities for students to pursue their passions and sharpen their skills like public speaking, communication, coding, etc. On the other hand, the HITAM Innovation and Incubation Center (HIIC) has been instrumental in creating successful startups, garnering accolades and grants from the Government of India.

As a testament to HITAMs commitment to quality education, it is accredited with NAAC A+ and NBA for its programs in Computer Science, Electronics and Communication, Electrical, and Mechanical Engineering. In addition to these, HITAM also offers courses in emerging technologies like Artificial Intelligence and Machine Learning, and Data Science.

The colleges achievements speak for themselves. HITAM is the first college in Telangana to become a member of the prestigious Grand Challenges Scholar Program (GCSP), with 16 students certified by the National Academy of Education, USA. Their structured career design program equips students with the necessary skills and guidance to realize their dreams, whether it be placements, entrepreneurship, higher education, or careers in defense services and the government sector.

HITAM has a diverse leadership team, consisting of alumni from esteemed institutions like IITs and ISB, along with senior officers from the armed forces, brings invaluable expertise and guidance to shape the students futures. HITAM also places a strong emphasis on student leadership and self-governance. The Student Self Governance (SSG) body acts as a bridge between the student community and the college leadership, empowering students to contribute to the decision-making process.

Moreover, HITAM entered into collaborations and partnerships with leading international universities and research institutions, like the University of Alabama in Huntsville, USA; RWTH Aachen University, Germany; Milwaukee School of Engineering, USA; Woosong University, South Korea; Penn HUB, Pennsylvania, USA; and EPICS from Purdue University. These partnerships open doors for student and faculty immersions, joint research projects, international conferences and workshops, ensuring a global perspective is built in education and research.

It is no wonder that companies like Goldman Sachs recognize the talent at HITAM, by conducting campus drives and selecting their students for prestigious internships with handsome stipends. The colleges track record of success speaks for itself, with HITAM being consistently ranked among the top engineering colleges in India by reputed publications.

HITAM believes in the all-round development of students and is one of the very few colleges which offer NCC. The NCC cadets of HITAM are winning accolades by participating in various camps. Students at HITAM also take an active part in NSS and contribute to society through volunteering activities. HITAM instills a sense of responsibility towards society amongst its students, and the culture to give has led to many NGOs being started by the students. Notable amongst these are NGOs like Sahaya and For a Cause, that are successfully running since many years.

It is essential for any higher educational institution to create a thriving environment that encourages excellence and enables innovation, resulting in holistic development. HITAM - with its various initiatives that result in an all round development - is the obvious first choice for any parent or student who aspires for holistic development through engineering.

For more information, visit http://www.hitam.org

Vamsi Koka BE, MS (UK), MBA (ISB)

Dean of Strategy and Operations

Hyderabad Institute of Technology and Management (HITAM)

Email: vamsi@hitam.org

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Published by Callum O'Reilly, Senior Editor Hydrocarbon Engineering, Tuesday, 01 Aug 23

Chart Industries Inc. has celebrated construction progress of its Teddy 2 facility, named as such because it is Charts second facility in Theodore, Alabama, US.

This plant is expected to fabricate the largest shop-built cryogenic tanks ever manufactured globally (70% larger than the previous largest), with manufacturing production set to begin in 1Q24. The tanks manufactured at this site will be used for propellant storage for the aerospace industry, hydrogen and LNG storage for the marine industry, and many other processes and technologies in the sciences and decarbonisation industries. Teddy 2s easy access to waterways will provide additional opportunities for our customers to have lower cost, faster freight and transportation to site.

In addition to the ability to manufacture to this scale, this expansion also contributes significantly to local job creation and economic development efforts for the state of Alabama. We have expectations that our Teddy 2 facility will achieve annual revenues in excess of US$175 million. This also benefits local subcontractors in Alabama for process that we outsource, including the US$7.2 million of improvements to the onsite wharf which were awarded in full to local businesses. Teddy 2 is anticipated to employ over 90 people across two shifts as we continue to receive orders for these applications.

Chart began construction of this greenfield 127 000 ft2 facility in Theodore, Alabama in early April 2023, and it is due to complete in April 2024.

Were thrilled to be expanding into our second facility in Theodore, Alabama, said Jill Evanko, CEO and President of Chart Industries. This location is ideal for its water access, access to a strong skilled workforce, and capabilities to leverage our Teddy 1 capabilities, all supporting our expansion to serve our customers that want larger cryogenic tanks built in America.

Brent Barkin, Mobile Chamber Chairman of the Board, said: On behalf of the Mobile Chamber, Id like to thank Chart Industries for choosing to invest in Mobile and its people, bringing a wealth of jobs to our region and further supporting our economic development efforts.

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Chart Industries celebrates construction progress of its Teddy 2 facility - Hydrocarbon Engineering