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The Dirt: Digging deep with professor of epidemiology Rod Jackson – Stuff.co.nz

Rod Jackson is a professor of epidemiology at the University of Auckland, a father of two and grandfather of two. He lives and gardens with his wife Barbara, a retired librarian, in Ponsonby.

Gardening is my therapy. I grew up on a beef and sheep farm just out of Dargaville. I felt an affinity with the land, theres a closeness. Now Ive got a garden on a small section. Any time I can, I get out there.

Im an identical twin. My brother is a semi-retired lawyer. It was reasonably competitive between us. That was something my father instilled in us. There were five boys, including two sets of twins. He liked everyone to compete against each other. He was a bit of a slave driver. I learnt from a really early age that you worked really hard seven days a week.

Jason Dorday/Stuff

Rod Jackson is a professor of epidemiology at the University of Auckland but loves to get out in his garden.

At the age of 15 I dont know the reason why, but I read this book called The Population Bomb. The basic premise was that unless we managed the worlds population there would be starvation and disease and wed be well and truly uhhh Thered be catastrophe. That was in the late 60s. It got me thinking about health for the first time, and about populations.

Barbara was my girlfriends best friend. That was around the beginning of university. A few years later we reconnected and ended up rapidly getting together. I think wed always had feelings for each other that had never been expressed.

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I was just going to be a normal doctor and I enjoyed clinical medicine, but I had a real interest in prevention. I remember I was working in a respiratory ward at Auckland Hospital. This lovely volunteer - Blue Cross ladies, we used to call them - went down to the hospital shop to buy cigarettes for a patient because he was too sick to get them himself. And I just thought this is bizarre, so I met with the hospital organisation committee and I said you should ban selling cigarettes at the hospital and they thought I was crazy. This is like 1976, 1977.

People knew I was a bit like that. So when there was a job for a junior doctor to go and work in public health someone said to me Hey Rod would you like to try this? This was now about 1980. So I ended up with this one-year job, working with an epidemiologist called Robert Beaglehole - this amazing guy, the key person behind New Zealands Smokefree Environments [Act]. And I just got sucked in and I never went back. I just loved it.

Jason Dorday/Stuff

I was just going to be a normal doctor and I enjoyed clinical medicine, but I had a real interest in prevention.

In March 2020, a colleague whod moved to Australia sent me a very simple model hed developed showing what the peak Covid infection rates would be by May, if there were no restrictions. I just remember seeing that chart and thinking oh my god, were dealing with a crisis.

No, I dont find it exciting. I find it terrifying. Im an academic epidemiologist, but Im also a public health doctor Every New Zealander who isnt vaccinated its a failure of me as their doctor.

The official number of deaths from Covid is 5 million but every epidemiologist knows thats a huge underestimate. Its probably 12 million up towards 15 to 20 million. In lower income countries many people who die dont even get a death certificate.

I get multiple emails every day from people who are angry about the things I say. They range from the anti-vaxxers to people who just dont like the fact that Im pushing mandates. Unless theyre death threats from whackos I try to answer them. And I have had people whove come around.

Jason Dorday/Stuff

Rod Jackson says he gets multiple emails every day from people who are angry about the things he says.

Mandates work. Yes they impact on peoples freedom, but this is war. This virus doesnt play by any rules. You talk about road maps? The virus doesnt drive. Its designed to do one thing, survive. It doesnt care if it kills you or not.

Im known as the butter cop. My work has mainly been in predicting the risk of heart disease. Eat less saturated fat, dont smoke, less salt, less sugar, and dont be sedentary. The five Ss.

Jason Dorday/Stuff

Jackson and his wife Barbara look after different parts of their garden.

I love wine. And I love ice cream. Ill have a couple of glasses of wine most nights and I have ice cream on the weekends. Favourite flavour? Probably... chocolate.

We have a bit of a demarcation in the garden. Barbara does all the flowers and I do all the vegetables. She tells me that I only let her have parts of the garden. But I love her garden out the front - this wild garden of shrubs and flowers. I just love watching things grow, building things. Im a bit of a dumpster diver. Around here people throw out amazingly good timber. Weve got a 400 sq metre section in Ponsonby. Weve been here since 1984. Its the only house weve ever had.

Jason Dorday/Stuff

Rod Jackson is a fan of square foot gardening, rather than planting in rows.

I had the most amazing mother. She had five kids under 5. She treated us all differently but she had no favourites. She died in 2019 and it kind of brings tears to my eyes. She left at the right time, she wouldnt have coped well with Covid, she was always out. She was a goer.

If youre not vaccinated youre going to get Delta once it gets loose, which is inevitable. This is my one goal. I have a one track mind. Get vaccinated.

Jason Dorday/Stuff

Rod Jackson has compost and a worm farm, as well as using sheep pellets, lime, blood and bone.

Rods gardening tips

- Use lots of fertiliser - Ive got a compost and a worm farm. I use sheep pellets, lime, blood and bone.

- Theres a book (and a site) called Square Foot Gardening. Rather than planting in rows, you garden in one foot square areas. I dont know why but I found it very liberating. It made it so much easier to experiment and companion plant.

- Make your own seed tape. You know those tiny little seeds like carrot seeds that are an absolute pain to plant? You just get toilet paper, fold it over once, put the seeds down along it, fold it on top of them again, moisten it and lay it out in your garden. Some people make a glue from flour and water but you don't need to, you just need to wet it slightly.

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Ways to help let go of resentment – ABC Life

Two weeks after Prisha* was diagnosed with a chronic health condition, her long-term relationship broke down.

(*Namechanged for privacy.)

"I was crying non-stop for weeks," she says.

"I had thought we would be married one day and envisioned my entire future alongside him."

After grieving the loss of her relationship, Prisha says another feeling began to replace the devastation.

"I became resentful about what had happened."

Stan Steindl, clinical psychologist and adjunct associate professor at the School of Psychology University of Queensland, says resentment is a complex and painful human emotion.

"Itrelates to a bitter disappointment coupled with anger and fear about having been insulted, wronged or treated unfairly by another person," Dr Steindl explains.

Not recognising people have the potential to be reactive during a break-up can leave us open to further hurt.

While resentment can serve a helpful purpose in signalling something we might need to address or correct, it can often become harmful.

Clinical psychologist and CEO of Relationships Australia New South Wales Elisabeth Shawsays it can lead to even more negative behaviours.

"It can be hard to reconcile or come to peace with what has happened, and that can lead to lingering anger, frustration, rumination and a need to keep discussing it with others," she says.

Dr Steindl adds that "human resentment can often turn into vengeance motivations, and a desire to 'teach them a lesson' or get some sort of 'payback'".

While Prisha says she never felt the need to seek vengeance, her resentment did begin to dominate her life.

"I would talk to my friends and family non-stop. I thought about it when I wasn't talking about it."

While resentment is a commonly experienced emotion, it can negatively impact our mental health, relationships with others and self-esteem.

"Chronic resentment can be a precursor to anxiety and depressive disorders, relationship distress and dysfunction, withdrawal and isolation and sometimes aggression and violence," says Dr Steindl.

For Prisha, constantly feeling resentful left her emotionally exhausted and began to impact her mental health.

"This is when I knew I needed some assistance," she says.

Seeking professional support can help you work through resentment and any related issues.

This was the best option for Prisha.

"I've been working with a psychologistand it has helped me deal with what happened in a more positive way," she says.

"I still have a way to go but I'm confident eventually I will fully let go of the resentment that was holding me back."

Resentment arises from your threat system (an emotional system of the brain, often known as the fight/flight/freeze/appease response designed to help us with threat protection), and specifically some aspect of social threat.

Identifying the threat and feeling of resentment is the first step in addressing it, says Dr Steindl.

Resentment is related to sympathetic nervous system activation, so we want to try to slow down the body and the mind by activating the parasympathetic nervous system.Activities like meditation, massageand deep breathing can help do this.

One exercise Dr Steindl recommends that can help ease body tension and calm the mind: Sit in an upright but relaxed position, relax your face,soften your self-talk so you'reusing supportive inner voice tones, and slow down your breath, breathing in for four and out for four.

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To practise forgiveness and move towards a feeling of ease and peace of mind, Dr Steindl suggests the following exercise:

From this place of calm, Dr Steindl says you can start to consider: What would be most helpful in this situation? What could I do that would help to bring balance back to the needs of both parties? What is it that I really need right now from this relationship?

Resentment can cause us to be "narrowly focused", says Dr Steindl, so to help expand your attentiondo meaningful activities you enjoy with friends and family who make you feel good.

This is general information only. For detailed personal advice, you should see a qualified medical practitioner who knows your medical history.

Shona Hendley is a freelance writer and ex-secondary school teacher from Ballarat, Victoria. She lives with her four fish, three goats, two cats, one chicken, as well as her two human children and husband. Find her@shonamarion.

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How to Deal With Social Anxiety During the Holidays – The New York Times

Sarah Ahmed, co-founder of Wellnest, a psychotherapy clinic in Toronto, agreed. I know for me, I cap out at two events a week, a number that was much higher prepandemic, she said. Use your body, she suggested, as an indicator to tell if youve reached capacity. Our bodies are constantly talking to us, said Ahmed. Common symptoms of social anxiety, she said, include exhaustion, headaches, sweating, difficulty speaking, nausea and increased heart rate. If you are feeling particularly fatigued after a social event, Id revisit future commitments that week.

If youre turning down an invitation, Mr. Lerman said, do it as early as possible, and keep your explanation brief and polite. (That sounds fun, but I will need to pass this time, or Thanks for the invite, but I already have plans.)

On the day of a holiday get-together, vow to be extra gentle with yourself, said Dr. Bryant. Do things that you know will soothe and calm you, like playing music beforehand that puts you in a festive mood.

Make a post-event plan of self-care, too, she advised. It may be that you promise yourself, Im going to have a bubble bath after and a hot cup of green tea, or maybe you schedule a call with a person that you trust, and as soon as you get in that parking lot you know you can call them to debrief.

If you are feeling overwhelmed at an event, create a little space to reorient yourself. Depending on the neighborhood, you can take a quick walk, just to get fresh air, said Dr. Bryant. If the walls are closing in at a family affair, volunteer to be the errand person: Oh, we didnt get enough butter? Ill go!

And its a perfectly acceptable conversation-starter to acknowledge and normalize the awkwardness during this transitional phase, said Ahmed. You can say, My brain is remembering how to socialize, so pardon me if Im still a bit rusty.

If you only feel up to attending an event for an hour, tell the host as soon as possible, said Monica Lewis, co-founder (with her husband, Darian) of the Monica Lewis School of Etiquette in Houston. Or you can ask when the best time would be to swing by. They may say, Oh, make sure youre here for the cocktail hour, or I dont want you to miss the gift exchange, Ms. Lewis said.

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How to Deal With Social Anxiety During the Holidays - The New York Times

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What We Will Never Know – Gizmodo

There is a realm the laws of physics forbid us from accessing, below the resolving power of our most powerful microscopes and beyond the reach of our most sensitive telescopes. Theres no telling what might exist thereperhaps entire universes.

Since the beginning of human inquiry, there have been limits to our observing abilities. Worldviews were restricted by the availability of tools and our own creativity. Over time, the size of our observable universe grew as our knowledge grewwe saw planets beyond Earth, stars beyond the Sun, and galaxies beyond our own, while we peered deeper into cells and atoms. And then, during the 20th century, mathematics emerged that can explain, shockingly welland, to a point, predictthe world we live in. The theories of special and general relativity describe exactly the motion of the planets, stars, and galaxies. Quantum mechanics and the Standard Model of Particle Physics have worked wonders at clarifying what goes on inside of atoms.

However, with each of these successful theories comes hard-and-fast limits to our observing abilities. Today, these limits seem to define true boundaries to our knowledge.

On the large end, there is a speed limit that caps what we can see. It hampers any hope for us to observe most of our universe first-hand.

The speed of light is approximately 300,000,000 meters per second (or 671,000,000 miles per hour, if thats how your brain works). The theory of special relativity, proposed by Albert Einstein in 1905, forbids anything from traveling faster than that. Massless things always travel this speed in a vacuum. Accelerating massive objects to this speed essentially introduces a divide-by-zero in one of special relativitys equations; it would take infinite energy to accelerate something with mass to the speed of light.

If, as a child, you hopped on a spaceship traveling out of the solar system at 99% the speed of light, you might be able to explore other parts of the galaxy before succumbing to age, but because time is relative, your friends and family would likely be long gone before you could report your observations back to Earth. But youd still have your limitsthe Milky Way galaxy is 105,700 light-years across, our neighboring galaxy Andromeda is 2.5 million light-years away, and the observable universe is around 93 billion light-years across. Any hope of exploring farther distances would require multigenerational missions or, if using a remote probe, accepting that youll be dead and humanity may be very different by the time the probes data returns to Earth.

The speed of light is more than just a speed limit, however. Since the light we see requires travel time to arrive at Earth, then we must contend with several horizons beyond which we cant interact, which exist due to Einsteins theory of general relativity. There is an event horizon, a moving boundary in space and time beyond which light and particles emitted now will never reach Earth, no matter how much time passesthose events we will never see. There is also the particle horizon, or a boundary beyond which we cannot observe light arriving from the pastthis defines the observable universe.

Theres a second kind of event horizon, one surrounding a black hole. Gravity is an effect caused by the presence of massive objects warping the shape of space, like a bowling ball on a trampoline. A massive-enough object might warp space such that no information can exit beyond a certain boundary.

These limits arent static. We will see further and further as time goes on, because the distance light travels outward gets bigger and bigger, said Tamara Davis, astrophysics professor who studies cosmology at the University of Queensland. But this expanding perspective wont be permanentsince our universe is also expanding (and that expansion is accelerating). If you fast-forward 100 billion years into the future, all of the galaxies that we can currently see will be so far, and accelerating so quickly away from us, that the light they emitted in the past will have faded from view. At that point, our observable universe would be just those nearby galaxies gravitationally bound to our own.

Another boundary lives on the other end of the scale. Zoom in between molecules, into the center of atoms, deep into their nuclei and into the quarks that make up their protons and neutrons. Here, another set of rules, mostly devised in the 20th century, governs how things work. In the rules of quantum mechanics, everything is quantized, meaning particles properties (their energy or their location around an atomic nucleus, for example) can only take on distinct values, like steps on a ladder, rather than a continuum, like places on a slide. However, quantum mechanics also demonstrates that particles arent just dots; they simultaneously act like waves, meaning that they can take on multiple values at the same time and experience a host of other wave-like effects, such as interference. Essentially, the quantum world is a noisy place, and our understanding of it is innately tied to probability and uncertainty.

This quantum-ness means that if you try to peer too closely, youll run into the observer effect: Attempting to see things this small requires bouncing light off of them, and the energy from this interaction can fundamentally change that which youre attempting to observe.

But theres an even more fundamental limit to what we can see. Werner Heisenberg discovered that the wonkiness of quantum mechanics introduces minimum accuracy with which you can measure certain pairs of mathematically related properties, such as a particles position and momentum. The more accurately you can measure one, the less accurately you can measure the other. And finally, even attempting to measure just one of those properties becomes impossible at a small enough scale, called the Planck scale, which comes with a shortest length, 10^-35 meters, and a shortest time interval, around 5 x 10^-44 seconds.

You take the constant numbers that describe naturea gravitational constant, the speed of light, and Plancks constant, and if I put these constants together, I get the Planck length, said James Beacham, physicist at the ATLAS experiment of the Large Hadron Collider. Mathematically, its nothing specialI can write down a smaller number like 10^-36 meters But quantum mechanics says that if I have a prediction to my theory that says structure exists at a smaller scale, then quantum has built-in uncertainty for it. Its a built-in limit to our understanding of the universethese are the smallest meaningful numbers that quantum mechanics allows us to define.

This is assuming that quantum mechanics is the correct way to think about the universe, of course. But time and time again, experiments have demonstrated theres no reason to think otherwise.

These fundamental limits, large and small, present clear barriers to our knowledge. Our theories tell us that we will never directly observe what lies beyond these cosmic horizons or what structures exist smaller than the Planck scale. However, the answers to some of the grandest questions we ask ourselves might exist beyond those very walls. Why and how did the universe begin? What lies beyond our universe? Why do things look and act the way that they do? Why do things exist?

The unobservable and untestable exist beyond the scope of scientific inquiry. Alls well and good to write down the math and say you can explain the universe, but if you have no way of testing the hypothesis, then thats getting outside the realm of what we consider science, said Nathan Musoke, a computational cosmologist at the University of New Hampshire. Exploring the unanswerable belongs to philosophy or religion. Its possible, however, that science-derived answers to these questions exist as visible imprints on these horizons that the scientific method can uncover.

That imprinting is literal. Ralph Alpher and Robert Herman first predicted in 1948 that some light left over from an early epoch in the universes history might still be observable here on Earth. Then, in 1964, Arno Penzias and Robert Wilson were working as radio astronomers at Bell Labs in New Jersey, when they noticed a strange signal in their radio telescope. They went through every idea to figure out the source of the noiseperhaps it was background radiation from New York City, or even poop from pigeons nesting in the experiment? But they soon realized that the data matched Alpher and Hermans prediction.

Penzias and Wilson hadspotted the microwave radiation from just 400,000 years after the Big Bang called the cosmic microwave background, the oldest and most distant radiation observable to todays telescopes. During this era in the universes history, chemical reactions caused the previously opaque universe to allow light to travel through uninhibited. This light, stretched out by the expanding universe, now appears as faint microwave radiation coming from all directions in the sky.

Astronomers experiments since then, such as the Cosmic Background Explorer (COBE), the Wilkinson Microwave Anisotropy Probe (WMAP), and the Planck space observatory have attempted to map this cosmic microwave background, revealing several key takeaways. First, the temperature of these microwaves is eerily uniform across the skyaround 2.725 degrees above absolute zero, the universes minimum temperature. Second, despite its uniformity, there are small, direction-dependent temperature fluctuations; patches where the radiation is slightly warmer and patches where its slightly cooler. These fluctuations are a remnant of the structure of the early universe before it became transparent, produced by sound waves pulsing through it and gravitational wells, revealing how the earliest structures may have formed.

At least one theory has allowed for a scientific approach to probing this structure, with hypotheses that have been tested and supported by further observations of these fluctuations. This theory is called inflation. Inflation posits that the observable universe as we see it today would have once been contained in a space smaller than any known particle. Then, it underwent a burst of unthinkable expansion lasting just a small fraction of a second, governed by a field with dynamics determined by quantum mechanics. This era magnified tiny quantum-scale fluctuations into wells of gravity that eventually governed the large-scale structure of the observable universe, with those wells written into the cosmic microwave background data. You can think of inflation as part of the bang in the Big Bang theory.

Its a nice thought, that we can pull knowledge from beyond the cosmic microwave background. But this knowledge leads to more questions. I think theres a pretty broad consensus that inflation probably occurred, said Katie Mack, theoretical astrophysicist at North Carolina State University. Theres very little consensus as to how or why it occurred, what caused it, or what physics it obeyed when it happened.

Some of these new questions may be unanswerable. What happens at the very beginning, that information is obscured from us, said Mack. I find it frustrating that were always going to be lacking information. We can come up with models that explain what we see, and models that do better than others, but in terms of validating them, at some point were going to have to just accept that theres some unknowability.

At the cosmic microwave background and beyond, the large and the small intersect; the early universe seems to reflect quantum behaviors. Similar conversations are happening on the other end of the size spectrum, as physicists attempt to reconcile the behavior of the universe on the largest scale with the rules of quantum mechanics. Black holes exist in this scientific space, where gravity and quantum physics must play together, and where physical descriptions of whats going on sit below the Planck scale.

Here, physicists are also working to devise a mathematical theory that, while too small to observe directly, produces observable effects. Perhaps most famous among these ideas is string theory, which isnt really a theory but a mathematical framework based on the idea that fundamental particles like quarks and electrons arent just specks but one-dimensional strings whose behavior governs those particles properties. This theory attempts to explain the various forces of nature that particles experience, while gravity seems to be a natural result of thinking about the problem in this way. Like those studying any theory, string theorists hope that their framework will put forth testable predictions.

Finding ways to test these theories is a work in progress. Theres faith that one way or another we should be able to test these ideas, said David Gross, professor at the Kavli Institute for Theoretical Physics and winner of the 2004 Nobel Prize in Physics. It might be very indirectbut thats not something thats a pressing issue.

Searching for indirect ways to test string theory (and other theories of quantum gravity) is part of the search for the theory itself. Perhaps experiments producing small black holes could provide a laboratory to explore this domain, or perhaps string theory calculations will require particles that a particle accelerator could locate.

At these small timescales, our notion of what space and time really is might break down in profound ways, said Gross. The way physicists formulate questions in general often assumes various givens, like spacetime exists as a smooth, continuous manifold, he said. Those questions might be ill formulated. Often, very difficult problems in physics require profound jumps, revolutions, or different ways of thinking, and its only afterward when we realize that we were asking the question in the wrong way.

For example, some hope to know what happened at the beginning of the universeand what happened before time began. That, I believe, isnt the right way to ask the question, said Gross, as asking such a question might mean relying on an incorrect understanding of the nature of space and time. Not that we know the correct way, yet.

Walls that stop us from easily answering our deepest questions about the universe well, they dont feel very nice to think about. But offering some comfort is the fact that 93 billion light-years is very big, and 10^-35 meters is very small. Between the largest and the smallest is a staggering space full of things we dont but theoretically can know.

Todays best telescopes can look far into the distance (and remember, looking into the distance also means looking back in time). Hubble can see objects as they were just a few hundred million years after the Big Bang, and its successor, the Webb Space Telescope, will look farther still, perhaps 150 million years after the Big Bang. Existing galactic surveys like the Sloan Digital Sky Survey and the Dark Energy Survey have collected data on millions of galaxies, the latter having recently released a 3D map of the universe with 300 million galaxies. The upcoming Vera C. Rubin Observatory in Chile will survey up to 10 billion galaxies across the sky.

From an astronomy point of view, we have so much data that we dont have enough people to analyze it, said Mikhail Ivanov, NASA Einstein Fellow at the Institute for Advanced Study. There are so many things we dont understand in astrophysicsand were overwhelmed with data. To question whether were hitting a limit is like trolling. Even then, these mind-boggling surveys represent only a small fraction of the universes estimated 200 billion galaxies that future telescopes might be able to map.

But as scientists attempt to play in these theoretically accessible spaces, some wonder whether the true limit is us.

Today, particle physics seems to be up against an issue of its own: Despite plenty of outstanding mysteries in need of answers, the physicists at the Large Hadron Collider have found no new fundamental particles since the Higgs Boson in 2012. This lack of discovery has physicists scratching their heads; its ruled out the simplest versions of some theories that had been guiding particle physicists previously, with few obvious signposts about where to look next (though there are some!).

Beacham thinks that these problems could be solved by searching for phenomena all the way down to the Planck scale. A vast, unknown chasm exists between the scale of todays particle physics experiments and the Planck scale, and theres no guarantee of anything new to discover in that space. Exploring the entirety of that chasm would take an immense amount of energy and increasingly powerful colliders. Quantum mechanics says that higher-momentum particles have smaller wavelengths, and thus are needed to probe smaller length scales. However, actually exploring the Planck scale may require a particle accelerator big enough to circle the Sunmaybe even one the size of the solar system.

Maybe its daunting to think of such a collider, but its inspiration for a way to get to the scaleand inspiration to figure out how to get there with a smaller device, he said. Beacham views it as particle physicists duty to explore whether any new physical phenomena might exist all the way down to the Planck scale, even if there currently isnt evidence theres anything to find. We need to think about going as high in energy as we can, building larger and larger colliders until we hit the limit. We dont get to choose what the discoveries are, he said.

Or, perhaps we can use artificial intelligence to create models that perfectly explain the behavior of our universe. Zooming back out, Fermilab and University of Chicago scientist Brian Nord has dreamed up a system that could model the universe with the help of artificial intelligence, constantly and automatically updating its mathematical model with new observations. Such a model could grow arbitrarily close to the model that actually describes our universeit could generate a theory of everything. But, as with other AI algorithms, it would be a black box to humans.

Such issues are already cropping up in fields where we use software-based tools to make accurate models, explained Taner Edis, physicist at Truman State University. Some software toolsmachine learning models, for examplemay accurately describe the world we live in but are too complex for any individual to completely understand. In other words, we know that these tools work, but not necessarily how. Maybe AI will take us farther down this path, where the knowledge we create will exist spread over a civilization and its technology, owned in bits and pieces by humanity and the algorithms we create to understand the universe. Together, wed have generated a complete picture, but one inaccessible to any single person.

Finally, these sorts of models may provide supreme predictive power, but they wouldnt necessarily offer comfortable answers to questions about why things work the way they do. Perhaps this sets up a dichotomy between what scientists can domake predictions based on initial conditionsand what they hope these predictions will allow them to dolead us to a better understanding of the universe we live in.

I have a hunch that well be able to effectively achieve full knowledge of the universe, but what form will it come in? said Nord. Will we be able to fully understand that knowledge, or will it be used merely as a tool to make predictions without caring about the meaning?

Thinking realistically, todays physicists are forced to think about what society cares about most and whether our systems and funding models permit us to fully examine what we can explore, before we can begin to worry about what we cant. U.S.legislators often discuss basic science research with the language of applied science or positive outcomesthe Department of Energy funds much particle physics research. The National Science Foundations mission is To promote the progress of science; to advance the national health, prosperity, and welfare; and to secure the national defense; and for other purposes.

Physicists hoping to receive funding must compete for resources in order to do research that promotes the missions of these organizations. While many labs, such as CERN, exist solely to fund peaceful research with no military applications, most still brag that indirectly solving bigger problems will lead to new techthe internet, or advances in data handling and AI, for example. Private funding organizations exist, but they, too, are either limited in their resources, driven by a mission, or both.

But what if answering these deep questions requires thinking that isnt driven by anything? How can scientists convince funders that we should build experiments, not with the hope of producing new technology or advancing society, but merely with the hope of answering deep questions? Echoing a sentiment expressed in an article by Vanessa A. Bee, what if our systems today (sorry, folks, Im talking about capitalism) are actually stifling innovation in favor of producing some short-term gain? What if answering these questions would require social policy and international collaboration deemed unacceptable by governments?

If this is indeed the world we live in, then the unknowable barrier is far closer than the limits of light speed and the Planck scale. It would exist because we collectivelythe governments we vote for, the institutions they funddont deem answering those questions important enough to devote resources to.

Prior to the 1500s, the universe was simply Earth; the Sun, Moon, and stars were small satellites that orbited us. By 1543, Nicolaus Copernicus proposed a heliocentric model of the universethe Sun sat at the center, and Earth orbited it. It was only in the 1920s that Edwin Hubble calculated the distance of Andromeda and proved the Milky Way wasnt the whole universe; it was just one of many, many galaxies in a larger universe. Scientists discovered most of the particles that make up todays Standard Model of particle physics in the second half of the 20th century. Sure, relativity and quantum theory seem to have established the size of the sandbox we have to play inbut precedent would suggest theres more to the sandbox, or even beyond the sandbox, that we havent considered. But then, maybe there isnt.

There are things that well never know, but thats not the right way to think about scientific discovery. We wont know unless we attempt to know, by asking questions, crafting hypotheses, and testing them with experiments. The vast unknown, both leading up to and beyond our boundaries, presents limitless opportunities to ask questions, uncover more knowledge, and even render previous limits obsolete. We cannot truly know the unknowable, then, since the unknowable is just what remains when we can no longer hypothesize and experiment. The unknowable isnt factits something we decide.

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Pistoia Alliance predicts a focus on the fight against antimicrobial resistance and a surge in quantum computing research for 2022 – Bio-IT World

Boston, US, 22 November 2021: The Pistoia Alliance, a global, not-for-profit alliance that advocates for greater collaboration in life sciences R&D, has today outlined predictions for the life sciences industry in 2022. The predictions come from three experts recently appointed by the Alliance to drive collaboration efforts across its three key themes. Their insights span the urgent fights against antimicrobial resistance, the potential of quantum computing and commercial space travel, and autonomous laboratories. Throughout 2021, digital transformation has continued to accelerate and the pharmaceutical industry has further embraced collaboration, both of which will underpin success in emerging areas in the next 12 months.

Linda Kasim, Empowering the Patient theme lead, Pistoia Alliance: In 2022, the renewed focus on the fight against super bugs and antimicrobial resistance (AMR) will be prioritized. This will be primarily driven by public-private partnerships, funding from philanthropic organizations, governments and international bodies to incentivize research. The public sector must quickly increase investment into AMR research, or the cost to national economies and public health could be devastating. mRNA technologies will represent a rapid and valuable platform to be further exploited for vaccines against AMR infections.

Digital health platforms will also be more integrated seeking efficiency through harmonized data generation. The use of Self-Sovereign Identities within healthcare solutions will expand. For these breakthroughs to happen, regulatory authorities must catch-up with the pace of research and innovation in health systems in 2022 by updating legal frameworks.

Imran Haq, Emerging Science and Technology theme lead, Pistoia Alliance: Driven by macro geopolitical trends and Big Tech, emerging technologies are being developed increasingly rapidly. Reflecting this, deal making in the quantum space will continue to grow a pace in 2022. As the buzz around the sector increases, will this be the year we finally start to see translation of this buzz into early versions of applications and use cases in the pharma industry? A likely quantum use case could be to improve supply chain efficiency. Big promises have been made during COP26, and large organizations, including pharma companies, must have net zero strategies. This is also an area we would like to explore with the Pistoia Alliances Quantum Computing Community of Interest.

Pharma is also going to play an increasingly critical role in space exploration. As plans to launch a commercial space stationfrom companies like Blue Origin accelerate, pharma should be engaged to ensure humans are healthy and can survive in the long term in extreme environments. 2022 is the time to think how we could be molding and driving forward health in space.

Anca Ciobanu, Improving the Efficiency and Effectiveness of R&D theme lead, Pistoia Alliance: Efficiency in R&D is on an exponential growth path as more pharma and biotech organizationspartner with AI and robotics companies, enabling a more automated drug discovery process. In 2022, the major tech players will increase their focus on the life sciences and will play an important role in developing new products and initiatives. The application of new technologies will not only empower scientists to conduct experiments more efficiently, but it will also help them make more breakthrough discoveries. As companies continue to invest resources in launching or improving their autonomous labs, researchers will need upskilling in data science, to be able to program and interact with themachines.

The Pistoia Alliance has more than 150 member companies including major life science companies, technology and service providers, academic groups, publishers, and patient research groups. Members collaborate as equals on projects that generate value for the worldwide life sciences and healthcare ecosystem. To find out more about the Alliance and its portfolio of projects, click here: https://www.pistoiaalliance.org/category/projects/.

--ENDS

About The Pistoia Alliance:

The Pistoia Alliance is a global, not-for-profit members organization made up of life science companies, technology and service providers, publishers, and academic groups working to lower barriers to innovation in life science and healthcare R&D. It was conceived in 2007 and incorporated in 2009 by representatives of AstraZeneca, GSK, Novartis and Pfizer who met at a conference in Pistoia, Italy. Its projects transform R&D through pre-competitive collaboration. It overcomes common R&D obstacles by identifying the root causes, developing standards and best practices, sharing pre-competitive data and knowledge, and implementing technology pilots. There are currently over 150 member companies; members collaborate on projects that generate significant value for the worldwide life sciences R&D community, using The Pistoia Alliances proven framework for open innovation.

Media Contacts:

Spark Communications

+44 207 436 0420

pistoiaalliance@sparkcomms.co.uk

Tanya Randall

The Pistoia Alliance

+44 7887 811332

tanya.randall@pistoiaalliance.org

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Pistoia Alliance predicts a focus on the fight against antimicrobial resistance and a surge in quantum computing research for 2022 - Bio-IT World

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The Future of Quantum Computing – The Business Standard

Quantum computing could be the solution to the challenges that are faced by quantum physicists. It has the power to change our fundamental understanding of reality, and it could soon become a reality.

Quantum computing is an area of research in which engineers, scientists, and technologists are trying to build a computer where information is represented at the quantum level.

Quantum computers would be able to solve problems that are not possible with classical computers or solve them much more quickly. Today's silicon-based computer chips use binary digits (bits) with values of either 0 or 1 for storing information. These bits exist in two states at any given time and can't represent both 0 and 1 simultaneously like qubits which can represent all values at once thanks to the quantum mechanics principle called superpositioning.

Classical Computers VS Quantum ComputersTo understand how quantum computing works, it's important to know the difference between the old (classical) way of computing and the new (quantum) way.

On classical computers, information is encoded into binary digits called "bits." These bits can be in one of two states: 0 or 1. A qubit also has two possible states - 0, 1, or both at once (superposition). This means that it can encode much more information than a binary digit. The physical world behaves according to quantum mechanics. So theoretically, if we want to simulate physical phenomena on a computer, we should use quantum mechanical principles as well

Now that we have made the switching and memory units of computers, known as transistors, almost as small as an atom, we need to find an entirely new way of thinking about and building computers. Quantum computers are not intended to replace classical computers, they are expected to be a different tool we will use to solve complex problems that are beyond the capabilities of a classical computer. A problem that requires more power and time than today's computers can accommodate is called an intractable problem. These are the problems that quantum computers are predicted to solve.

When you enter the world of atomic and subatomic particles, things begin to behave in unexpected ways. It's this ability that quantum computers take advantage of. By entering into this quantum area of computing where the traditional laws of physics no longer apply, we will be able to create processors that are significantly faster than the ones we use today. Sounds fantastic, but the challenge is that quantum computing is also incredibly complex.

That's precisely why the computer industry is racing to make quantum computers work on a commercial scale.

Quantum computers are different from traditional computers because they use quantum bits (qubits) instead of binary bits. One qubit can be in two states at the same time, which solves many problems that current computers don't. Moreover, quantum computing can solve highly complex problems by using "parallelism" to process many calculations at the same time. The downside to this technology is that it needs an enormous amount of energy for operations to work properly. For instance, IBM has said that qubits need about 100 milliwatts of power per operation whereas regular processors need about 10 kilowatts

The Quantum Revolution

The practical uses of quantum computers are still being researched and tested. In the future, it is possible that quantum computers will be able to solve problems that have been impossible to solve before. For example, they have the potential to be used for modelling molecules or predicting how a molecule will behave under different conditions.

We should also remember that a quantum computer is not faster than a regular computer - it's just more powerful. That means that "running" a program on a quantum computer will take just as long as on a regular computer - but with much better results because of their increased power.Quantum computers will allow for the storage and processing of data in ways that we cannot even comprehend today. They also offer more complex calculations than traditional computers and therefore can easily solve problems that would take years to solve on a traditional computer.

Some experts believe that they could be used to calculate complex formulas with no time limit, which will make them an invaluable tool in medical science, AI technologies, aeronautical engineering and so on. So far, quantum computing has been used to solve optimization problems, which are too complex for traditional computer models. It's also been used to study protein folding and drug interactions within the body.

Quantum computers are powerful computers that work on the principles of quantum mechanics. They use qubits, not bits to represent data and they can access potentially more than two values at the same time. Quantum computers will be able to break all of the encoding and encryption we have today. Quantum computing is changing the world of cybersecurity. Quantum computers are capable of running sophisticated simulations in parallel, making them much faster than classical computers. The ability to run simulations in parallel means that quantum computers can quickly find solutions to difficult problems. Quantum computers will disrupt many industries like finance, healthcare, and education.

While it's still unclear how big of an impact quantum computing will have on marketing in the future, there are already some significant uses happening now. One example is in ad targeting where companies can analyze customer behaviour with astounding precision by processing large amounts.

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The Future of Quantum Computing - The Business Standard

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Einsteins notes on theory of relativity fetch record 11.6m at auction – The Guardian

Albert Einsteins handwritten notes on the theory of relativity fetched a record 11.6m (9.7m) at an auction in Paris on Tuesday.

The manuscript had been valued at about a quarter of the final sum, which is by far the highest ever paid for anything written by the genius scientist.

It contains preparatory work for the physicists signature achievement, the theory of general relativity, which he published in 1915.

Calling the notes without a doubt the most valuable Einstein manuscript ever to come to auction, Christies which handled the sale on behalf of the Aguttes auction house had estimated prior to the auction that it would fetch between 2m and 3m.

Previous records for Einsteins works were $2.8m for the so-called God letter in 2018, and $1.56m in 2017 for a letter about the secret to happiness.

The 54-page document was handwritten in 1913 and 1914 in Zurich, Switzerland, by Einstein and his colleague and confidant Michele Besso, a Swiss engineer.

Christies said it was thanks to Besso that the manuscript was preserved for posterity. This was almost like a miracle, it said, since Einstein would have been unlikely to hold on to what he considered to be a simple working document.

Today the paper offered a fascinating plunge into the mind of the 20th centurys greatest scientist, Christies said. It discusses his theory of general relativity, building on his theory of special relativity from 1905 that was encapsulated in the equation E=mc2.

Einstein died in 1955 aged 76, lauded as one of the greatest theoretical physicists of all time. His theories of relativity revolutionised his field by introducing new ways of looking at the movement of objects in space and time.

In 1913 Besso and Einstein attacked one of the problems that had been troubling the scientific community for decades: the anomaly of the planet Mercurys orbit, Christies said.

This initial manuscript contains a certain number of unnoticed errors, it added. Once Einstein spotted them, he let the paper drop, and it was taken away by Besso.

Scientific documents by Einstein in this period, and before 1919 generally, are extremely rare, Christies said. Being one of only two working manuscripts documenting the genesis of the theory of general relativity that we know about, it is an extraordinary witness to Einsteins work.

Einstein also made major contributions to quantum mechanics theory and won the Nobel physics prize in 1921. He became a pop culture icon thanks to his dry witticisms and trademark unruly hair, moustache and bushy eyebrows.

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The future is Bitcoin according to South Park creators – Cointelegraph

South Park, the animated TV series that often tackles topical issues with a comedic twist, showed Bitcoin being used as a mainstream means of payment in the not too distant future.

In the Post COVID episode of its 24th season which aired Thursday, South Park depicted one of the shows protagonists, Stan Marsh, paying for a stay in a cheap motel using Bitcoin (BTC) roughly 40 years from now, when the pandemic is jokingly about to end for good. The fictional Super 12 Motel Plus in a future where nearly all brand names have plus and maxx included only accepts Bitcoin and other cryptocurrency, with the show having Marsh pay using a plastic card with the BTC logo and a QR code.

Its the future weve all decided centralized banking is rigged so we trust more in fly-by-night Ponzi schemes, said the motel clerk.

Many in the crypto space know South Park for its criticism of the United States governments and banks response following the 2008 financial crisis, popularized by the meme aaaand... its gone referring to Marsh losing money immediately after depositing it in a bank. Among the other future predictions in the recent episode are autonomous vehicles, holographic digital assistants and stand-up comedy becoming a shadow of itself amid woke culture.

Though referencing cryptocurrency and blockchain in mainstream media is somewhat commonplace now, this wasnt always the case. The first TV series to feature BTC was The Good Wife in January 2012, but others have gone on to use the emerging technology and financial tool for both comedy and drama. This year, James Spaders character in The Blacklist claimed to know the true identity of Satoshi, and The Simpsons showed the BTC price moving to infinity on an animated stock ticker feed.

Related: Reality show is casting crypto users locked out of their wallets

Bitcoin's appearance on the popular animated series comes as the price of the crypto asset has stayed mostly under $60,000 for more than a week. According to data from Cointelegraph Markets Pro, the BTC price is $59,237 at the time of publication, having fallen more than 14% since reaching an all-time high of $69,000 on Nov. 10.

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Stripe says it’s open to accepting crypto for payments, three years after ending bitcoin support – CNBC

Stripe isn't ruling out accepting cryptocurrency as a method of payment in the future, according to co-founder John Collison.

The online payments company ended support for bitcoin payments in 2018, citing the digital coin's notoriety for volatile price swings and a lack of efficiency in making everyday transactions.

"Crypto obviously means a lot of different things to a lot of different people," Collison said at a CNBC-moderated panel at the Fintech Abu Dhabi festival on Tuesday.

Collison said there were some aspects to crypto such as its use as a speculative investment that are "not that relevant to what we do at Stripe."

But, he added: "There have been a lot of developments of late with an eye to making cryptocurrencies better and, in particular, scalable and acceptable cost as a payment method."

Asked whether Stripe would start accepting crypto as a method of payment again, Collison said: "We don't yet, but I think it's not implausible that we would."

The company recently formed a team dedicated to exploring crypto and "Web3," a buzzword in tech that refers to a new, decentralized version of the internet.

The effort is being led by Guillaume Poncin, Stripe's head of engineering. Earlier this month, the company appointed Matt Huang, co-founder of crypto-focused venture capital firm Paradigm, to its board of directors.

Collison said there are a number of innovations emerging in digital assets that have potential, including solana a competitor to ethereum, the world's second-biggest digital currency to "Layer 2" systems like bitcoin's Lightning Network, which aim to speed up transactions and process them at a lower cost.

Founded in 2009, Stripe has quickly become the largest privately-held fintech company in the U.S. The company was last valued at $95 billion and counts the likes of Baillie Gifford, Sequoia Capital and Andreessen Horowitz as investors.

The company, which processes payments for the likes of Google, Amazon and Uber, has expanded into a number of other areas in finance lately, including loans and tax management.

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Pokmon GO Creator’s AR Platform Is Now Being Used To Hunt Bitcoin, Not Pocket Monsters – Nintendo Life

Image: Fold

Niantic, the studio being the smartphone hit Pokmon GO, has lent its AR platform to payments company Fold to create a new kind of 'catch 'em all' adventure but this time, players are hunting for the cryptocurrency Bitcoin rather than monsters.

Payments company Fold has leveraged Niantic's AR platform to create an in-app experience where users can earn Bitcoin by exploring a virtual environment based on their immediate surroundings, described by the firm as a "real-world metaverse".

Users will be able to discover and collect Bitcoin and other prizes around them using the app. Every 10 minutes, a new block containing a fresh prize is dropped in the vicinity of a player. By claiming the block, the user earns 'Satoshis', the smallest unit of Bitcoin, alongside other rewards. However, if you collect a 's**tcoins' or 'Poison Pills', you could end up losing all of the Bitcoin you've collected.

Here's how Fold describes the experience on its blog it's even cheeky enough to use a gif of Mario collecting coins in Super Mario World:

The AR experience acts as a natural extension of the Fold App which already gives you the ability to earn bitcoin going about your daily life: buying coffee, going shopping, paying bills, and even paying your taxes. While the experience is open to anyone, Fold Cardholders can collect extra spins and rewards boosts to increase their rewards on the Fold Card.

The complete experience will drop next year and will enable individuals to find, trade, and hide bitcoin and other rewards throughout the world IRL, and will also give merchants the ability to engage the community with incentives and offers. It all started with someone saying lets make PokemonGo but for bitcoin and ended with lets build a new way to exchange and share bitcoin with others.

Fold CEO Will Reeves also had this to say:

This is the easiest, most fun way to get your first piece of Bitcoin. Anyone can use our [Fold] app to earn Bitcoin and other rewards by exploring the world around them. For us, it's always been important to make participating in the Bitcoin economy easy for anyone, regardless of education or technical expertise.

What do you make of this venture? Let us know with a comment.

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